Flexyx

Flexyx drugs: Periactinol

Periactinol - General Information:

A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc. [PubChem]

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Generic Periactin (Cyproheptadine) - 4mg 100 tabs for $31.00 Periactin (Cyproheptadine) is an antihistamine used to treat or prevent symptoms of hay fever and other allergies. It is used to relieve itching associated with some skin conditions and to treat other conditions as determined by your doctor. It may also be used for a hormone disorder (cushing's syndrome), sexual function problems due to certain drugs, and eating disorders (anorexia nervosa).

Pharmacology:

Periactinol is a piperidine antihistamine. Unlike other antihistamines, this drug also antagonizes serotonin receptors. This action makes Periactinol useful in conditions such as vascular headache and anorexia. Periactinol does not prevent the release of histamine but rather competes with free histamine for binding at HA-receptor sites. Periactinol competitively antagonizes the effects of histamine on HA-receptors in the GI tract, uterus, large blood vessels, and bronchial smooth muscle. Most antihistamines possess significant anticholinergic properties, but Periactinol exerts only weak anticholinergic actions. Blockade of central muscarinic receptors appears to account for Periactinol's antiemetic effects, although the exact mechanism is unknown. Periactinol also competes with serotonin at receptor sites in smooth muscle in the intestines and other locations. Antagonism of serotonin on the appetite center of the hypothalamus may account for Periactinol's ability to stimulate appetite. Periactinol also has been used to counter vascular headaches, which many believe are caused by changes in serotonin activity, however it is unclear how Periactinol exerts a beneficial effect on this condition.

Periactinol for patients

Antihistamines may diminish mental alertness; conversely, particularly, in the young child, they may occasionally produce excitation. Patients should be warned about engaging in activities requiring mental alertness and motor coordination, such as driving a car or operating machinery.

Periactinol Interactions

MAO inhibitors prolong and intensify the anticholinergic effects of antihistamines. Antihistamines may have additive effects with alcohol and other CNS depressants, e.g., hypnotics, sedatives, tranquilizers, antianxiety agents.

Periactinol Contraindications

Newborn or Premature Infants

This drug should not be used in newborn or Premature infants.

Nursing Mothers

Because of the higher risk of antihistamines for infants generally and for newborns and prematures in particular, antihistamine therapy is contraindicated in nursing mothers.

Other Conditions

Hypersensitivity to cyproheptadine and other drugs of similar chemical structure. Monoamine oxidase inhibitor therapy

• Angle-closure glaucoma
• Stenosing peptic ulcer
• Symptomatic prostatic hypertrophy
• Bladder neck obstruction
• Pyloroduodenal obstruction
• Elderly, debilitated patients

Additional information about Periactinol

Periactinol Indication: For treatment of perennial and seasonal allergic rhinitis, vasomotor rhinitis, allergic conjunctivitis due to inhalant allergens and foods, mild uncomplicated allergic skin manifestations of urticaria and angioedema, amelioration of allergic reactions to blood or plasma, cold urticaria, dermatographism, and as therapy for anaphylactic reactions adjunctive to epinephrine.
Mechanism Of Action: Periactinol competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding.
Drug Interactions: Donepezil Possible antagonism of action
Fluoxetine Possible antagonism of action
Galantamine Possible antagonism of action
Metyrapone This combination renders test invalid
Rivastigmine Possible antagonism of action
Food Interactions: Take with food.
Avoid alcohol.
Generic Name: Cyproheptadine
Synonyms: Not Available
Where to order Cyproheptadine (and Periactinol analogs) online:
Drug Category: Anti-Allergic Agents; Gastrointestinal Agents; Antipruritics; Antihistamine derivatives
Drug Type: Small Molecule; Approved
Other Brand Names containing Cyproheptadine: Cypoheptadine; Cyproheptadiene; Cyproheptadine Hcl; Dibenzosuberonone/Cyproheptadine; Dronactin; Eiproheptadine; Periactin; Periactine; Periactinol; Peritol;
Absorption: Well absorbed after oral administration.
Toxicity (Overdose): Not Available
Protein Binding: 96 to 99%
Biotransformation: Hepatic (cytochrome P-450 system) and some renal.
Half Life: Not Available
Dosage Forms of Periactinol: Tablet Oral
Syrup Oral
Chemical IUPAC Name: Not Available
Chemical Formula: C21H21N
Cyproheptadine on Wikipedia: http://en.wikipedia.org/wiki/Cyproheptadine
Organisms Affected: Humans and other mammals