Peritol - General Information:A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc. [PubChem]
Other Brand Names containing Cyproheptadine
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Peritol - Pharmacology:
Peritol is a piperidine antihistamine. Unlike other antihistamines, this drug also antagonizes serotonin receptors. This action makes Peritol useful in conditions such as vascular headache and anorexia. Peritol does not prevent the release of histamine but rather competes with free histamine for binding at HA-receptor sites. Peritol competitively antagonizes the effects of histamine on HA-receptors in the GI tract, uterus, large blood vessels, and bronchial smooth muscle. Most antihistamines possess significant anticholinergic properties, but Peritol exerts only weak anticholinergic actions. Blockade of central muscarinic receptors appears to account for Peritol's antiemetic effects, although the exact mechanism is unknown. Peritol also competes with serotonin at receptor sites in smooth muscle in the intestines and other locations. Antagonism of serotonin on the appetite center of the hypothalamus may account for Peritol's ability to stimulate appetite. Peritol also has been used to counter vascular headaches, which many believe are caused by changes in serotonin activity, however it is unclear how Peritol exerts a beneficial effect on this condition.
Peritol for patients
Antihistamines may diminish mental alertness; conversely, particularly, in the young child, they may occasionally produce excitation. Patients should be warned about engaging in activities requiring mental alertness and motor coordination, such as driving a car or operating machinery.
MAO inhibitors prolong and intensify the anticholinergic effects of antihistamines. Antihistamines may have additive effects with alcohol and other CNS depressants, e.g., hypnotics, sedatives, tranquilizers, antianxiety agents.
Newborn or Premature Infants
This drug should not be used in newborn or Premature infants.
Because of the higher risk of antihistamines for infants generally and for newborns and prematures in particular, antihistamine therapy is contraindicated in nursing mothers.
Hypersensitivity to cyproheptadine and other drugs of similar chemical structure. Monoamine oxidase inhibitor therapy
- Angle-closure glaucoma
- Stenosing peptic ulcer
- Symptomatic prostatic hypertrophy
- Bladder neck obstruction
- Pyloroduodenal obstruction
- Elderly, debilitated patients
Indication, Mechanism Of Action, Drug Interactions, Food Interactions, etc..