Placidyl - General Information:

Placidyl is a sedative and hypnotic drug. It has been used to treat insomnia, but has been largely superseded and is only offered where an intolerance or allergy to other drugs exists. [Wikipedia]

Pharmacology:

Placidyl is a sedative drug and schedule IV (USA) controlled substance. It produces cerebral depression, however the exact mechanism of action is not known.

Placidyl for patients

Avoid driving and other activities requiring alertness while taking this medication. Avoid alcohol and other depressants. Effects may take 2 nights before any benefits are noticed.

Placidyl Interactions

Dicumarol and warfarin may decrease hypoprothrombinemic effect. Other depressasnts such as alcohol, barbiturates, and MAOIs may enhance CNS depression when administered with ethchlorvynol.

Placidyl Contraindications

Contraindicated in patients exhibiting hypersensitivity to this drug, in patients with severe pain, and in patients with porphyria.

Additional information about Placidyl

Placidyl Indication: Used for short-term hypnotic therapy in the management of insomnia for periods of up to one week in duration; however, this medication generally has been replaced by other sedative-hypnotic agents.
Mechanism Of Action: Although the exact mechanism of action is unknown, ethchlorvynol appears to depress the central nervous system in a manner similar to that of barbiturates. Barbiturates bind at a distinct binding sites associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.
Drug Interactions: Anisindione Placidyl decreases the anticoagulant effect
Dicumarol Placidyl decreases the anticoagulant effect
Acenocoumarol Placidyl decreases the anticoagulant effect
Warfarin Placidyl decreases the anticoagulant effect
Food Interactions: Take with food to reduce irritation.
Avoid alcohol
Generic Name: Ethchlorvynol
Synonyms: Aethyl-chlorvynol; Ethochlorvynol; Ethychlorvynol; Ethclorvynol; Ethchlorvinyl; Ethchlorvinol; Ethchlorovynol; Etchlorvinolo
Drug Category: Hypnotics and Sedatives
Drug Type: Small Molecule; Illicit; Approved
Other Brand Names containing Ethchlorvynol: Alvinol; Arvynol; Normonson; Normosan; Normoson; Nostel; Nromoson; Placidil; Placidyl; Roeridorm; Serenesil; Serenil; Serensil; Serensiloline;
Absorption: Rapidly absorbed from gastrointestinal tract.
Toxicity (Overdose): Symptoms of overdose include thrombocytopenia.
Protein Binding: 35-50%
Biotransformation: About 90% of a dose is metabolized in the liver. Some ethchlorvynol may also be metabolized in the kidneys. Ethchlorvynol and metabolites undergo extensive enterohepatic recirculation.
Half Life: Plasma half-life is approximately 10 to 20 hours, terminal half-life is 21-100 hours.
Dosage Forms of Placidyl: Capsule Oral
Chemical IUPAC Name: 1-chloro-3-ethylpent-1-en-4-yn-3-ol
Chemical Formula: C7H9ClO
Ethchlorvynol on Wikipedia: http://en.wikipedia.org/wiki/Ethchlorvynol
Organisms Affected: Humans and other mammals

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