Pramil - General Information:

Pramil (marketed by Eli Lilly and Company under the brand names SeconalĀ® and Tuinal) is a barbiturate derivative drug. It possesses anaesthetic, anticonvulsant, sedative and hypnotic properties. In the United Kingdom, it was known as Quinalbarbitone.

Pharmacology:

Pramil, a barbiturate, is used for the induction of anesthesia prior to the use of other general anesthetic agents and for induction of anesthesia for short surgical, diagnostic, or therapeutic procedures associated with minimal painful stimuli. Little analgesia is conferred by barbiturates; their use in the presence of pain may result in excitation.

Pramil for patients

Pramil Interactions

Barbiturates may decrease the effectiveness of oral contraceptives, certain antibiotics, quinidine, theophylline, corticosteroids, anticoagulants, and beta blockers.

Pramil Contraindications

Additional information about Pramil

Pramil Indication: For the Short-term treatment of intractable insomnia for patients habituated to barbiturates
Mechanism Of Action: Pramil binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Secobarbital
Synonyms: (+/-)-Secobarbital; Secobarbital Sodium; Secobarbitale [DCIT]; Secobarbitalum [INN-Latin]; Sodium quinalbarbitone; Sodium Secobarbital
Drug Category: Hypnotics and Sedatives; Adjuvants; Barbiturates
Drug Type: Small Molecule; Approved
Other Brand Names containing Secobarbital: Barbosec; Bipanal; Bipinal sodium; Evronal; Evronal Sodium; Evrronal; Hypotrol; Hyptran; Imesonal; Immenoctal; Immenox; Meballymal; Meballymal sodium; Meballymalum; Novosecobarb; Pramil; Quinalbarbital; Quinalbarbitone; Quinalbarbitone sodium; Quinalspan; Sebar; Seco 8; Secobarbitone; Seconal; Sedutain; Seotal; Somosal; Synate; Trisomnin;
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Pramil: Not Available
Chemical IUPAC Name: 5-[(2R)-pentan-2-yl]-5-prop-2-enyl-1,3-diazinane-2,4,6-trione
Chemical Formula: C12H18N2O3
Secobarbital on Wikipedia: http://en.wikipedia.org/wiki/Secobarbital
Organisms Affected: Humans and other mammals

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