Pre-pen - General Information:

Pre-pen is used as a skin-testing reagent to detect immunoglobulin E antibodies in people with a history of penicillin allergy. The quantitation of in vitro IgE antibodies to the benzylpenicilloyl determinant is a useful tool for evaluating allergic subjects.


Benylpenicilloyl polylysine is penicilloyl bound to polylysine and is considered to be the major determinant of penicillin metabolism; it is used as a skin-testing reagent to detect immunoglobulin E antibodies in people with a history of penicillin allergy. If skin testing using benzylpenicilloyl and penicillin G (as the sole source of minor determinants) is negative, approximately 97% of patients with a negative skin test will tolerate penicillin.

Pre-pen for patients

Pre-pen Interactions

Pre-pen Contraindications

Skin testing for detection of reagin with specific haptenes is never without risk. Skin testing patients known to be extremely hypersensitive to penicillin should not be done unless there is a very strong medical reason for administering penicillin.

Additional information about Pre-pen

Pre-pen Indication: For use as a adjunct in assessing the risk of administering penicillin (benzylpenicillin or penicillin G).
Mechanism Of Action: The skin test for penicillin demonstrates the presence or absence of specific IgE antibodies to major and minor penicillin determinants. IgE antibodies to major determinants can be detected by using benzylpenicilloyl polylysine. A penicillin skin test predicts only the presence of IgE antibodies for the major or minor penicillin determinants at the time of application and does not predict the future development of IgE-mediated reactions during subsequent courses of penicillin. Benzylpenicilloyl polylysine reacts specifically with penicilloyl skin sensitizing antibodies (reagins) to produce immediate wheal and flare reactions which may reflect increased risk of allergic reactions to subsequent penicillin therapy.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Benzylpenicilloyl Polylysine
Synonyms: Not Available
Drug Category: Not Available
Drug Type: Small Molecule; Approved
Other Brand Names containing Benzylpenicilloyl Polylysine: Pre-pen;
Absorption: Not Available
Toxicity (Overdose): Symptoms of overdose include urticaria, generalized pruritus, local swelling, generalized flushing, anaphylaxis, bronchospasm, fainting and maculopapular eruption.
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Pre-pen: Liquid Intradermal
Chemical IUPAC Name: 2-[2-[(6-hydroxy-6-oxohexyl)amino]-2-oxo-1-[(2-phenylacetyl)amino]ethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
Chemical Formula: C22H31N3O6S
Benzylpenicilloyl Polylysine on Wikipedia: Not Available
Organisms Affected: Humans and other mammals

Bookmark or Share this page

»Get link codes for this page«
(HTML/BB code)

Search by name browsing our [A-Z] index:


Search by Categories:

See a list of all drugs for sale »

Top5 meds in current month:

*based on number of page views on Flexyx

Visit our friends:

brand and generic ed pills Russian Scientific Center for Restorative Traumatology and Orthopaedics in the name of academician G.A.Ilizarov

Related News

Thu, 09 Feb 2012
Buckhead Betty on a Budget - Love is Like a New Planner
And while I snapped all of these shots pre-pen-hitting-paper, I have been enjoying using my planner every.
Source: »

Fri, 18 Nov 2011
Can't take penicillin - This simple PRE-PEN test may change that - Simple test to check ...
Simple test to check for penicillin allergy. Simple test to check for penicillin allergy Many people are allergic to penicillin but a simple test is allowing many patients to safely use the popular antibiotic.
Source: »

Fri, 18 Nov 2011
Have an allergy - Can you grow out of it - Latest local news, weather and ...
James Wolf, along with three other doctors, manufactures the Pre Pen test and hopes to turn a profit from it. He says the test gives patients a chance to benefit from penicillin and 40 other medications in the same class of drugs.
Source: »

Thanks for visiting us!