Preludin hydrochloride - General Information:

A sympathomimetic drug used primarily as an appetite depressant. Its actions and mechanisms are similar to dextroamphetamine. [PubChem]

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Preludin hydrochloride - Pharmacology:

Preludin hydrochloride is a sympathomimetic drug used primarily as an appetite depressant. Its actions and mechanisms are similar to dextroamphetamine. Amphetamines are non-catecholamine sympathomimetic amines with CNS stimulant activity. Preludin hydrochloride was originally sold under the tradename Preludin as an anorectic. It has since been removed from the market. It is by some considered to have a greater potential for addiction than the amphetamines, and has been abused in many countries, for example Sweden.

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Preludin hydrochloride Interactions

Acetazolamide - administration may increase serum concentration of phenmetrazine.
Alcohol - may increase serum concentration of phenmetrazine.
Ascorbic acid -lowering urinary pH, may enhance phenmetrazine excretion.
Furazolidone - phenmetrazine may induce a hypertensive response in patients taking furazolidone.
Guanethidine - phenmetrazine inhibits the antihypertensive response to guanethidine.
Haloperidol - limited evidence indicates that haloperidol may inhibit the effects of phenmetrazine but the clinical importance of this interaction is not established.
Lithium carbonate - isolated case reports indicate that lithium may inhibit the effects of phenmetrazine.
Monoamine oxidase inhibitor - severe hypertensive reactions have followed the administration of phenmetrazine to patients taking monoamine oxidase inhibitors.
Noradrenaline - phenmetrazine abuse may enhance the pressor response to noradrenaline.
Phenothiazines - phenmetrazine may inhibit the antipsychotic effect of phenothiazines, and phenothiazines may inhibit the anorectic effect of phenmetrazine.
Sodium bicarbonate - large doses of sodium bicarbonate inhibit the elimination of phenmetrazine, thus increasing the phenmetrazine effect.
Tobacco smoking - phenmetrazine appears to induce dose-related increases in cigarette smoking.
Tricyclic antidepressants - theoretically increases the effect of phenmetrazine, but clinical evidence is lacking.

Preludin hydrochloride Contraindications

Anorexia, insomnia, psychopathic personality disorders, suicidal tendencies, Gilles de la Tourette syndrome and other disorders, hyperthyroidism, narrow angle glaucoma, diabetes mellitis and cardiovascular diseases such as angina, hypertension and arrythmias (Dollery, 1991; Reynolds, 1996).

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