Prepidil - General Information:

Prepidil, is a naturally occurring prostaglandin E2 (PGE2). It has important effects in labour. It also stimulates osteoblasts to release factors which stimualtes bone resorption by osteoclasts. As a prescription drug it is used as a vaginal suppository, to prepare the cervix for labour and to induce labour.

Pharmacology:

Prepidil is equivalent to prostaglandin E2 (PGE2). It stimulates labor and delivery and thus terminates pregnancy. Prepidil is also capable of stimulating the smooth muscle of the gastrointestinal tract of man. This activity may be responsible for the vomiting and/or diarrhea that is not uncommon when dinoprostone is used to terminate pregnancy.

Prepidil for patients

Prepidil Interactions

PROSTIN E2 may augment the activity of other oxytocic drugs. Concomitant use with other oxytocic agents is not recommended.

Prepidil Contraindications

  1. Hypersensitivity to dinoprostone
  2. Acute pelvic inflammatory disease
  3. Patients with active cardiac, pulmonary, renal, or hepatic disease

Additional information about Prepidil

Prepidil Indication: For the termination of pregnancy from the 12th through the 20th gestational week as calculated from the first day of the last normal menstrual period. Also for evacuation of the uterine contents in the management of missed abortion or intrauterine fetal death up to 28 weeks of gestational age as calculated from the first day of the last normal menstrual period, and also used in the management of nonmetastatic gestational trophoblastic disease (benign hydatidiform mole).
Mechanism Of Action: Prepidil administered intravaginally stimulates the myometrium of the gravid uterus to contract in a manner that is similar to the contractions seen in the term uterus during labor, resulting in the evacuation of the products of conception from the uterus.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Dinoprostone
Synonyms: Dinoprostone Prostaglandin E2; PGE2; Prostaglandin E2
Drug Category: Oxytocics; Prostaglandins
Drug Type: Small Molecule; Approved
Other Brand Names containing Dinoprostone: Cervidil; Prepidil; Prostarmon E; Prostin E; Prostin E2; Propess;
Absorption: Absorbed at a rate of 0.3 mg per hour over 12 hours while the vaginal system is in place.
Toxicity (Overdose): Oral, mouse: LD50 = 750 mg/kg; Oral, rat: LD50 = 500 mg/kg.
Protein Binding: 73%, to albumin
Biotransformation: Rapid metabolism of dinoprostone occurs primarily in the local tissues; any systemic absorption of the medication is cleared mainly in the maternal lungs and, secondarily, at sites such as the liver and kidneys.
Half Life: Less than 5 minutes.
Dosage Forms of Prepidil: Insert Intravaginal
Tablet Oral
Gel Endocervical (intracervical)
Gel Intravaginal
Chemical IUPAC Name: 7-[(1R,2R,3R)-3-hydroxy-2-[(3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]hept-5-enoic acid
Chemical Formula: C20H32O5
Dinoprostone on Wikipedia: http://en.wikipedia.org/wiki/Dinoprostone
Organisms Affected: Humans and other mammals

Bookmark or Share this page


»Get link codes for this page«
(HTML/BB code)



Search by name browsing our [A-Z] index:

ABCDEFGHI
JKLMNOPQR
STUVWXYZ

Search by Categories:

See a list of all drugs for sale »

Top5 meds in current month:

*based on number of page views on Flexyx

Visit our friends:

brand and generic ed pills Russian Scientific Center for Restorative Traumatology and Orthopaedics in the name of academician G.A.Ilizarov

Related News

Tue, 10 Apr 2012
Dinoprostone-prostaglandin-e2 (Prostin E2, Prepidil) - Drug Dosage and Side Effects - Healthline
What is this medicine. What may interact with this medicine. How should I use this medicine. What side effects may I notice from receiving this medicine. What should I tell my health care provider before I take this medicine.
Source: www.healthline.com »

Sat, 24 Mar 2012
Dinoprostone-prostaglandin-e2-1 (Prostin E2, Prepidil) - Drug Dosage and Side Effects - Healthline
What is this medicine. What may interact with this medicine. How should I use this medicine. What side effects may I notice from receiving this medicine. What should I tell my health care provider before I take this medicine.
Source: www.healthline.com »

Thu, 10 Nov 2011
From Inside the Puzzle - Raising a Child with Autism Blog - From the Archives - Birth Story
During the last week of my pregnancy, the doctors even ordered Prepidil Gel for my cervix in hopes of helping it ripen.
Source: community.advanceweb.com »



Thanks for visiting us!