Procef - General Information:

Procef is a cephalosporin antibiotic. It can be used to treat bronchitis, ear infections, skin infections, and other bacterial infections.

Pharmacology:

Procef, a semisynthetic, second-generation cephalosporin, is used to treat otitis media, soft-tissue infections, and respiratory tract infections.

Procef for patients

Cefprozil is an antibiotic use to treat infections such as tonsillitis, ear infections, bronchitis, pneumonia or skin infections. This drug should not be used by those with allergies to the cephalosporin antibiotics. You should also consult with your pharmacist or physician if you are allergic to penicillin before taking this medication. This medication contains phenylalanine; caution is warranted for phenylketonuric patients. This medication has been known to falsely wshow glucose (sugar) in the urine. The most common side effects include nausea, vomiting and diarrhea. This medication should be taken for the full period prescribed. Even if you feel better after a day or two of medication, the full prescription should be taken to fully cure the infection.

Procef Interactions

Nephrotoxicity has been reported following concomitant administration of aminoglycoside antibiotics and cephalosporin antibiotics. Concomitant administration of probenecid doubled the AUC for cefprozil.

The bioavailability of the capsule formulation of cefprozil was not affected when administered 5 minutes following an antacid.

Procef Contraindications

Cefprozil is contraindicated in patients with known allergy to the cephalosporin class of antibiotics.

Additional information about Procef

Procef Indication: For the treatment of the following infections (respiratory, skin, soft tissue, UTI, ENT) caused by; S. pneumoniae, H. influenzae, staphylococci, S. pyogenes (group A beta-hemolytic streptococci), E. coli, P. mirabilis, Klebsiella sp, coagulase-negative staph
Mechanism Of Action: Procef, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefprozil interferes with an autolysin inhibitor.
Drug Interactions: Probenecid Probenecid increases the antibiotic's level
Food Interactions: Take without regard to meals.
Generic Name: Cefprozil
Synonyms: Cefprozilo [INN-Spanish]; Cefprozil anhydrous; Cefprozilum [INN-Latin]
Drug Category: Anti-Bacterial Agents; Cephalosporins
Drug Type: Small Molecule; Approved
Other Brand Names containing Cefprozil: Arzimol; Brisoral; Cronocef; Procef; Serozil;
Absorption: Oral bioavailability is approximately 95%.
Toxicity (Overdose): Single 5000 mg/kg oral doses of cefprozil caused no mortality or signs of toxicity in adult, weaning or neonatal rats, or adult mice. A single oral dose of 3000 mg/kg caused diarrhea and loss of appetite in cynomolgus monkeys, but no mortality.
Protein Binding: 36%
Biotransformation: Cefprozil is eliminated primarily by the kidneys
Half Life: 1.3 hours
Dosage Forms of Procef: Powder, for solution Oral
Tablet Oral
Chemical IUPAC Name: (6R,7R)-7-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-8-oxo-3-[(E)-prop-1-enyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Chemical Formula: C18H19N3O5S
Cefprozil on Wikipedia: http://en.wikipedia.org/wiki/Cefprozil
Organisms Affected: Enteric bacteria and other eubacteria

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