Regulin - General Information:

A guanidinium antihypertensive agent that acts by blocking adrenergic transmission.

Pharmacology:

Regulin is a guanidinium antihypertensive agent that acts by blocking adrenergic transmission. The precise mode of action is not clear. Although bethanidine may produce adverse effects, they are beneficial in severe hypertension and produce fewer side effects than guanethidine.

Regulin for patients

Caution in cardiovascular disease and in history of peptic ulceration.

Regulin Interactions

Regulin Contraindications

  • Phaeochromocytoma
  • Phaeochromocytoma, malignant
  • Heart failure
  • Adverse reaction to phenoxybenzamine
  • Adverse reaction to phentolamine mesilate
  • Adverse reaction to trimetaphan camsilate
  • Adverse reaction to diazoxide
  • Adverse reaction to hydralazine
  • Adverse reaction to other antihypertensives
  • Adverse reaction to betanidine

Additional information about Regulin

Regulin Indication: For the treatment of hypertension.
Mechanism Of Action: Regulin, a guanidine derivative, is a peripherally acting antiadrenergic agent. Regulin effectively decreases blood pressure by suppressing renin secretion or interfering with function of the sympathetic nervous system.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Bethanidine
Synonyms: Betanidin; Betanidine; Bethanidine sulfate
Drug Category: Adrenergic Agents; Antihypertensive Agents; Sympatholytics
Drug Type: Small Molecule; Approved
Other Brand Names containing Bethanidine: Esbatal; Regulin; Tenathan;
Absorption: Absorbed rapidly in the gastrointestinal tract following oral administration.
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: 9 hours (range 7 to 11 hours)
Dosage Forms of Regulin: Tablet Oral
Chemical IUPAC Name: (2S)-1-[(2E)-2-[(2S)-2,6-dicarboxy-2,3-dihydro-1H-pyridin-4-ylidene]ethylidene]-5,6-dihydroxy-2,3-dihydroindol-1-ium-2-carboxylate
Chemical Formula: C18H16N2O8
Bethanidine on Wikipedia: Not Available
Organisms Affected: Humans and other mammals

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