Rhymed - General Information:

Rhymed has been withdrawn in Canada. In November 2000, the Food and Drug Administration (FDA) issued a public health advisory against the use of the drug.


    Rhymed (PPA), a sympathomimetic agent structurally similar to pseudoephedrine, is used to treat nasal congestion. Rhymed is found in appetite suppressant formulations and with guaifenesinin in cough-cold formulations. In 2000, the FDA requested that all drug companies discontinue marketing products containing phenylpropanolamine, due to an increased risk of hemorrhagic stroke in women who used phenylpropanolamine.

    Rhymed for patients


    This medicine is used to treat nasal congestion caused by colds or hay fever. Your doctor may prescribe this medicine for
    other conditions as well.

    General Information

    This information is for educational purposes only. Not every known side effect, adverse effect, or drug interaction is in
    this database. If you have questions about your medicines, talk to your healthcare provider.

    Proper use of this medicine

    For proper use of this medicine, follow the directions on the package, unless otherwise instructed by your doctor. To use
    a nose spray: gently blow your nose. Then sit back and tilt your head back slightly. Place the tip of the spray container
    into the nose. Close off the other nostril with your other hand. Spray into the nose. Wait at least one minute in between
    sprays. After using, rinse the tip of the sprayer in hot water and dry. This prevents contamination.

    Missed Dose

    Take your next dose as soon as you remember. If it is time for your next dose, skip the missed dose and go back to your
    regular schedule. Do not double doses.


    Follow package directions for proper storage. Keep away from heat, moisture or light.

    Possible Side Effects

    Some common side effects reported with this medicine include:
    increase in nasal discharge
    If you experience other bothersome side effects, talk to your health care provider.
    Some common side effects with this medicine include:
    burning or stinging inside your nose
    Report any of the following to your doctor:
    or fainting spells
    difficulty breathing
    chest pain
    rapid heart beat
    increased sweating
    tingling or numbness in the hands or feet


    Do NOT use more that the recommended dose of this medicine.
    Do NOT use more of this medicine or longer than prescribed.
    Using this medicine longer that 3-5 days can cause a condition known as "rebound congestion".


    Seek medical attention immediately. For non emergencies, contact your local or regional poison control center

    Drug Interactions

    This medicine can cause in increase in toxic effects to the heart when taken with other stimulants. Avoid taking with:
    general anesthetics
    MAO inhibitors.
    Taking this medicine with the following herbs can cause increased side effects including high blood pressure and should be
    This medicine can interact with the following drugs:
    diuretics (water pills)
    drugs used for depression
    high blood pressure medications
    drugs used for migraine headaches
    For more information on specific drug interactions, talk to your doctor or pharmacist.


    Talk to your doctor about using this medicine during pregnancy or nursing to discuss any possible risks to you or your baby.

    More Information

    For more information about this medicine, talk to your healthcare provider.

    Rhymed Interactions

    Vasopressors, particularly metaraminol, may cause serious cardiac arrhythmias during halothane anesthesia and therefore should be used only with great caution or not at all.

    MAO Inhibitors - The pressor effect of sympathomimetic pressor amines is markedly potentiated in patients receiving monoamine oxidase inhibitors (MAOI). Therefore, when initiating pressor therapy in these patients, the initial dose should be small and used with due caution. The pressor response of adrenergic agents may also be potentiated by tricyclic antidepressants.

    Rhymed Contraindications

    Phenylephrine hydrochloride should not be used in patients with severe hypertension, ventricular tachycardia, or in patients who are hypersensitive to it or to any of the components.

    Rhymed more info

    Indication, Mechanism Of Action, Drug Interactions, Food Interactions, etc..

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