Sibelium - General Information:Sibelium is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity. It is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy.
Pharmacology:Sibelium is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity.
Additional information about SibeliumSibelium Indication: Used in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy.
Mechanism Of Action: Not Available
Drug Interactions: Not Available
Food Interactions: Take without regard to meals.
Generic Name: Flunarizine
Synonyms: Flunarizinum [inn-latin]; Flunarizina [inn-spanish]; 1-(Bis(4-fluorophenyl)methyl)-4-cinnamylpiperazine; (E)-1-[Bis-(p-fluorophenyl)methyl]-4-cinnamylpiperazine; Flunarizine Hydrochloride; flunarizine dihydrochloride
Drug Category: Anticonvulsants; Calcium Channel Blockers; Histamine H1 Antagonists; Vasodilator Agents
Drug Type: Small Molecule; Approved
Other Brand Names containing Flunarizine: Sibelium; Novo-Flunarizine; Apo-flunarizine capsules; Vertix; Zinasen; Issium; Fluvert; Flufenal;
Absorption: 85% following oral administration.
Toxicity (Overdose): Not Available
Protein Binding: 99% bound to plasma proteins
Biotransformation: Hepatic, to two metabolites via N-dealylation and hydroxylation.
Half Life: 18 days
Dosage Forms of Sibelium: Capsule Oral
Chemical IUPAC Name: 1-[bis(4-fluorophenyl)methyl]-4-[(E)-3-phenylprop-2-enyl]piperazine
Chemical Formula: C26H26F2N2
Flunarizine on Wikipedia: http://en.wikipedia.org/wiki/Flunarizine
Organisms Affected: Humans and other mammals
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