Flexyx

Flexyx drugs: Simvastatine [French]

Simvastatine [French] - General Information:

A derivative of lovastatin and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (hydroxymethylglutaryl COA reductases), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL receptors, it increases breakdown of LDL cholesterol. [PubChem]

Related offers from our Drug Store:

Vytorin (Simvastatin) - for $50.85 Vytorin is used for reducing total cholesterol, LDL cholesterol, and triglycerides and for increasing HDL cholesterol.

Zocor (Simvastatin) - for $36.79 High blood cholesterol is first treated with exercise, weight loss, and a diet low in cholesterol and saturated fats. When these measures fail, cholesterol-lowering medications such as simvastatin can be added. The National Cholesterol Education Program (NCEP) has published treatment guidelines for use of these medications. These treatment guidelines take into account the level of LDL cholesterol as well as the presence of other risk factors such as diabetes, hypertension, cigarette smoking, low HDL cholesterol level, and family history of early coronary heart disease. The effectiveness of the medication in lowering cholesterol is dose related. Blood cholesterol determinations are performed in regular intervals during treatment so that dosage adjustments can be made.

* >> all this drugs based on Simvastatin (usually they can be used instead of Simvastatine [French])

Related offer from MedStore:

Generic Zocor (Simcard) - 20mg 30 tabs for $38.10 Zocor (Simcard) is an hmg-coa reductase inhibitor or 'statin' used to lower bad cholesterol (LDL) and triglyceride levels in your blood or to raise good cholesterol (HDL) levels in adults. This medicine is used in combination with a low-cholesterol and low-fat diet. Simvastatin may also be used in certain adolescent patients, age 10 to 17 years, who have a genetically caused cholesterol problem. This medicine works by blocking an enzyme that is necessary for your body to make cholesterol. When this enzyme is blocked, your body makes less cholesterol. Keeping your cholesterol level under control may reduce your risk of heart problems and stroke. This medicine is not a cure for high cholesterol, but may help to control it. This medicine may also be used to treat other conditions as determined by your doctor.

Pharmacology:

Simvastatine [French], the methylated form of lovastatin, is an oral antilipemic agent which inhibits HMG-CoA reductase. simvastatin is used in the treatment of primary hypercholesterolemia and is effective in reducing total and LDL-cholesterol as well as plasma triglycerides and apolipoprotein B.

Simvastatine [French] for patients

Patients should be advised about substances they should not take concomitantly with simvastatin and be advised to report promptly unexplained muscle pain, tenderness, or weakness. Patients should also be advised to inform other physicians prescribing a new medication that they are taking ZOCOR.

Simvastatine [French] Interactions

DRUG INTERACTIONS

CYP3A4 Interactions

Simvastatin is metabolized by CYP3A4 but has no CYP3A4 inhibitory activity; therefore it is not expected to affect the plasma
concentrations of other drugs metabolized by CYP3A4. Potent inhibitors of CYP3A4 (below) increase the risk of myopathy by reducing
the elimination of simvastatin.

Itraconazole

Ketoconazole

Erythromycin

Clarithromycin

Telithromycin

HIV protease inhibitors

Nefazodone

Cyclosporine

Large quantities of grapefruit juice (>1 quart daily)

Interactions with lipid-lowering drugs that can cause myopathy when given alone

Myopathy/Rhabdomyolysis.

The risk of myopathy is increased by gemfibrozil and to a lesser extent by other fibrates and niacin (nicotinic acid) (³1 g/day).

Other drug interactions

Danazol: The risk of myopathy/rhabdomyolysis is increased by concomitant administration of danazol particularly with higher doses of
simvastatin

Amiodarone or Verapamil: The risk of myopathy/rhabdomyolysis is increased by concomitant administration of amiodarone or verapamil
with higher doses of simvastatin

Propranolol: In healthy male volunteers there was a significant decrease in mean Cmax, but no change in AUC, for simvastatin total
and active inhibitors with concomitant administration of single doses of ZOCOR and propranolol. The clinical relevance of this
finding is unclear. The pharmacokinetics of the enantiomers of propranolol were not affected.

Digoxin: Concomitant administration of a single dose of digoxin in healthy male volunteers receiving simvastatin resulted in a slight
elevation (less than 0.3 ng/mL) in digoxin concentrations in plasma (as measured by a radioimmunoassay) compared to concomitant
administration of placebo and digoxin. Patients taking digoxin should be monitored appropriately when simvastatin is initiated.

Warfarin: In two clinical studies, one in normal volunteers and the other in hypercholesterolemic patients, simvastatin 20-40 mg/day
modestly potentiated the effect of coumarin anticoagulants: the prothrombin time, reported as International Normalized Ratio (INR),
increased from a baseline of 1.7 to 1.8 and from 2.6 to 3.4 in the volunteer and patient studies, respectively. With other reductase
inhibitors, clinically evident bleeding and/or increased prothrombin time has been reported in a few patients taking coumarin
anticoagulants concomitantly. In such patients, prothrombin time should be determined before starting simvastatin and frequently
enough during early therapy to ensure that no significant alteration of prothrombin time occurs. Once a stable prothrombin time has
been documented, prothrombin times can be monitored at the intervals usually recommended for patients on coumarin anticoagulants. If
the dose of simvastatin is changed or discontinued, the same procedure should be repeated. Simvastatin therapy has not been associated
with bleeding or with changes in prothrombin time in patients not taking anticoagulants.

Simvastatine [French] Contraindications

CONTRAINDICATIONS

Hypersensitivity to any component of this medication.

Active liver disease or unexplained persistent elevations of serum transaminases

Pregnancy and lactation. Atherosclerosis is a chronic process and the discontinuation of lipid-lowering drugs during
pregnancy should have little impact on the outcome of long-term therapy of primary hypercholesterolemia. Moreover,
cholesterol and other products of the cholesterol biosynthesis pathway are essential components for fetal development,
including synthesis of steroids and cell membranes. Because of the ability of inhibitors of HMG-CoA reductase such as
ZOCOR to decrease the synthesis of cholesterol and possibly other products of the cholesterol biosynthesis pathway,
ZOCOR is contraindicated during pregnancy and in nursing mothers. ZOCOR should be administered to women of childbearing
age only when such patients are highly unlikely to conceive. If the patient becomes pregnant while taking this drug, ZOCOR
should be discontinued immediately and the patient should be apprised of the potential hazard to the fetus.

Additional information about Simvastatine [French]

Simvastatine [French] Indication: For the treatment of hypercholesterolemia.
Mechanism Of Action: The 6-membered lactone ring of simvastatin is hydrolyzed in vivo to generate mevinolinic acid, an active metabolite structurally similar to HMG-CoA (hydroxymethylglutaryl CoA). Once hydrolyzed, simvastatin competes with HMG-CoA for HMG-CoA reductase, a hepatic microsomal enzyme. Interference with the activity of this enzyme reduces the quantity of mevalonic acid, a precursor of cholesterol.
Drug Interactions: Not Available
Food Interactions: Avoid drastic changes in dietary habit.
Avoid alcohol.
Avoid taking with grapefruit juice.
Generic Name: Simvastatin
Synonyms: Not Available
Where to order Simvastatin (and Simvastatine [French] analogs) online: Generic Zocor - Simvastatin (on DrugsPill.com)
Drug Category: Anticholesteremic Agents; Antilipemic Agents; Hydroxymethylglutaryl-CoA Reductase Inhibitors
Drug Type: Small Molecule; Approved
Other Brand Names containing Simvastatin: Cholestat; Coledis; Colemin; Corolin; Denan; Labistatin; Lipex; Lodales; Medipo; Nivelipol; Pantok; Rendapid; Simovil; Simvastatin [Usan:Ban:Inn]; Simvastatina [Spanish]; Simvastatine [French]; Simvastatinum [Latin]; Sinvacor; Sivastin; Synvinolin; Vasotenal; Vytorin; Zocor; Zocord;
Absorption: Absorption of simvastatin, estimated relative to an intravenous reference dose, in each of two animal species tested, averaged about 85% of an oral dose. In animal studies, after oral dosing, simvastatin achieved substantially higher concentrations in the liver than in non-target tissues.
Toxicity (Overdose): Not Available
Protein Binding: Both simvastatin and its b-hydroxyacid metabolite are highly bound (approximately 95%) to human plasma proteins.
Biotransformation: Hepatic, simvastatin is a substrate for CYP3A4.
Half Life: 3 hours
Dosage Forms of Simvastatine [French]: Tablet Oral
Chemical IUPAC Name: [(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate
Chemical Formula: C25H38O5
Simvastatin on Wikipedia: http://en.wikipedia.org/wiki/Simvastatin
Organisms Affected: Humans and other mammals