Flexyx

Flexyx drugs: Solvex

Solvex - General Information:

Solvex is an antidepressant drug used in the treatment of clinical depression, panic disorder and ADD/ADHD. Its mesylate (i.e. methanesulfonate) salt is sold under tradenames including Edronax, Norebox, Prolift, Solvex, Davedax or Vestra. Solvex has two chiral centers, but it only exists as two enantiomers, (R,R)-(-)- and (S,S)-(+)-reboxetine.

Pharmacology:

Solvex is a selective noradrenaline reuptake inhibitor (NaRI), the first
drug of new antidepressant class. Solvex is an a-ariloxybenzyl derivative of
morpholine. Solvex is primarily used to treat depression but has also been
found useful in the treatment of narcolepsy and panic disorders.

Solvex for patients

Solvex Interactions

Combined usage of MAO inhibitors should be avoided

Solvex Contraindications

Caution is recommended in patients with evidence of urinary retention and glaucoma

Additional information about Solvex

Solvex Indication: For the treatment of clinical depression.
Mechanism Of Action: Solvex is a selective inhibitor of noradrenaline reuptake. It inhibits
noradrenaline reuptake in vitro to a similar extent to the tricyclic
antidepressant desmethylimipramine. Solvex does not affect dopamine or
serotonin reuptake and it has low in vivo and in vitro affinity
for adrenergic, cholinergic, histaminergic, dopaminergic and serotonergic
receptors.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Reboxetine
Synonyms: Reboxetine mesylate
Where to order Reboxetine (and Solvex analogs) online:
Drug Category: Antidepressive Agents
Drug Type: Small Molecule; Approved
Other Brand Names containing Reboxetine: Edronax; Norebox; Vestra; Prolift; Solvex; Davedax;
Absorption: Reboxetine is rapidly and extensively absorbed following oral administration.
Toxicity (Overdose): Reports of seizures (rare) have been reported
Protein Binding: 98%
Biotransformation: Reboxetine is metabolized by dealkylation, hydroxylation and oxidation followed
by glucuronide or sulphate conjugation. It is metabolized by the cytochrome P450
CYP isoenzyme 3A4.
Half Life: 12.5 hours
Dosage Forms of Solvex: Tablet Oral
Chemical IUPAC Name: (2S)-2-[(S)-(2-ethoxyphenoxy)-phenylmethyl]morpholine
Chemical Formula: C19H23NO3
Reboxetine on Wikipedia: http://en.wikipedia.org/wiki/Reboxetine
Organisms Affected: Humans and other mammals