Sulfametizol [Inn-Spanish] - Pharmacology:

Sulfametizol [Inn-Spanish] is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.

Sulfametizol [Inn-Spanish] for patients

Take the drug with a full glass of water on an empty stomach. Increase fluid intake to 2L/day. Store in a tight, light-sensitive container at room temperature. Avoid sunlight or use sunscreen to prevent burns (avoid sunscreens containing PABA), avoid over-the-counter medications unless directed by a physician. Notify your doctor of skin rash, sore throat, fever, mouth sores, unusual bruising, and bleeding.

Sulfametizol [Inn-Spanish] Interactions

Sulfamethizole may increase the effects of barbiturates, tolbutamide, and uricosurics. It may also interact with thiazides (increased thrombocytopenia), cyclosporine (increased nephrotoxicity), sulfonylurea agents (increased hypoglycemic response), warfarin (increased anticoagulant effect), methotrexate (decreased renal excretion of methotrexate), phenytoin (decreased hepatic clearance of phenytoin).

Sulfametizol [Inn-Spanish] Contraindications

Treatment with Sulfamethizole is contraindicated in the following: hypersensitivity to sulfonamides and sulfonylureas, thiazide and loop diuretics, salicyclates, sunscreen with PABA, lactation, infants less than 2 months old, pregnancy at term, and porphyria.

Sulfametizol [Inn-Spanish] more info

Indication, Mechanism Of Action, Drug Interactions, Food Interactions, etc..