Sumatran - General Information:A serotonin agonist that acts selectively at 5HT1 receptors. It is used in the treatment of migraine disorders. A transdermal patch version of sumatriptan is currently in phase I trials in the U.S. under the code name NP101 (NuPathe).
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Pharmacology:Sumatran, an antimigraine drug, is structurally similar to serotonin. It is thought that the cerebral blood vessel constriction induced by activation of 5-HT1 receptors on those vessels may contribute to the antimigrainous effect of sumatriptan in humans.
Sumatran for patients
PATIENT PACKAGE INSERT
Please read this information carefully before you take sumatriptan succinate injection, tablets or nasal spray. This provides a
summary of the information available on your medicine. Please do not throw away this information until you have finished your
medicine. You may need to read this information again. This PATIENT PACKAGE INSERT does not contain all of the information on
sumatriptan succinate injection, tablets, or nasal spray. For further information or advice, ask your doctor or pharmacist.
Information About Your Medicine
The generic name of your medication is sumatriptan succinate. It can be obtained only with a prescription from your doctor. The
decision to use sumatriptan injection, tablets, or nasal spray is one that you and your doctor should make jointly, taking into
account your individual preferences and medical circumstances. If you have risk factors for heart disease (such as high blood
pressure, high cholesterol, obesity, diabetes, smoking, strong family history of heart disease, or you are postmenopausal or a male
over 40), you should tell your doctor, who should evaluate you for heart disease in order to determine if sumatriptan succinate is
appropriate for you. Although the vast majority of those who have taken sumatriptan succinate have not experienced any significant
side effects, some individuals have experienced serious heart problems and, rarely, considering the extensiveness of sumatriptan
succinate use worldwide, deaths have been reported. In all but a few instances, however, serious problems occurred in people with
known heart disease and it was not clear whether sumatriptan succinate was a contributory factor in these deaths.
The Purpose of Your Medicine
Injection: Sumatriptan succinate injection is intended to relieve your migraine or cluster headache, but not to prevent or reduce
the number of attacks you experience. Use sumatriptan succinate injection only to treat an actual migraine or cluster headache attack.
Tablets: Sumatriptan succinate tablets are intended to relieve your migraine, but not to prevent or reduce the number of attacks you
experience. Use sumatriptan succinate tablets only to treat an actual migraine attack.
Nasal Spray: Sumatriptan nasal spray is intended to relieve your migraine, but not to prevent or reduce the number of attacks you
experience. Use sumatriptan nasal spray only to treat an actual migraine attack.
Important Questions to Consider Before Taking Sumatriptan
If the answer to any of the following questions is YES or if you do not know the answer, then please discuss with your doctor before
you use sumatriptan succinate injection, tablets, or nasal spray.
Are you pregnant? Do you think you might be pregnant? Are you trying to become pregnant? Are you using inadequate contraception? Are
Do you have any chest pain, heart disease, shortness of breath, or irregular heartbeats? Have you had a heart attack?
Do you have risk factors for heart disease (such as high blood pressure, high cholesterol, obesity, diabetes, smoking, strong family
history of heart disease, or you are postmenopausal or a male over 40)?
Have you had a stroke, transient ischemic attacks (TIAs) or Raynaud syndrome?
Do you have high blood pressure?
Have you ever had to stop taking this or any other medication because of an allergy or any other problems?
Are you taking any other medications, including other 5-HT1 agonists or any other migraine medications containing ergotamine,
dihydroergotamine, or methysergide.
Are you taking any medication for depression (monoamine oxidase inhibitors or selective serotonin reuptake inhibitors [SSRIs])?
Have you had, or do you have, any disease of the liver or kidney?
Have you had, or do you have, epilepsy or seizures?
Is this headache different from your usual migraine attacks?
Remember, if you answered YES to any of the above questions, then discuss it with your doctor.
The Use of Sumatriptan Succinate During Pregnancy
Do not use sumatriptan succinate injection, tablets, or nasal spray if you are pregnant, think you might be pregnant, are trying to
become pregnant, or are not using adequate contraception, unless you have discussed this with your doctor.
How to Use Sumatriptan Succinate?
Injection: Before injecting sumatriptan succinate, check with your doctor on acceptable injection sites and see the instructions (on
or inside the carton) on discarding empty syringes and loading an autoinjector device.
Never reuse a syringe.
For adults, the usual dose is a single injection given just below the skin. It should be given as soon as the symptoms of your migraine
appear, but may be given at any time during an attack. A second injection may be given if your symptoms of migraine come back. If your
symptoms do not improve following the first injection, do not give a second injection for the same attack without first consulting with
your doctor. Do not have more than two injections in any 24 hours and allow at least 1 hour between each dose.
Tablets: For adults, the usual dose is a single tablet taken whole with fluids. A second tablet may be taken if your symptoms of migraine
come back or if you have a partial response to the initial dose, but not sooner than 2 hours following the first tablet. For a given
attack, if you have no response to the first tablet, do not take a second tablet without first consulting with your doctor. Do not take
more than a total of 200 mg of sumatriptan succinate tablets in any 24-hour period. The safety of treating an average of more than four
headaches in a 30-day period has not been established.
Nasal Spray: Before using sumatriptan nasal spray, see the enclosed instruction pamphlet. For adults, the usual dose is a single nasal
spray administered into one nostril. If your headache comes back, a second nasal spray may be administered anytime after 2 hours of
administering the first spray. For any attack where you have no response to the first nasal spray, do not take a second nasal spray
without first consulting with your doctor. Do not administer more than a total of 40 mg of sumatriptan nasal spray in any 24-hour
period. The effects of long-term repeated use of sumatriptan nasal spray on the surfaces of the nose and throat have not been specifically
studied. The safety of treating an average of more than four headaches in a 30-day period has not been established.
Side Effects to Watch For
Some patients experience pain or tightness in the chest or throat when using sumatriptan succinate injection, tablets, or nasal spray.
If this happens to you, then discuss it with your doctor before using any more sumatriptan succinate. If the chest pain is severe or
does not go away, call your doctor immediately.
If you have sudden and/or severe abdominal pain following sumatriptan succinate, call your doctor immediately.
Shortness of breath; wheeziness; heart throbbing; swelling of eyelids, face, or lips; or a skin rash, skin lumps, or hives happen
rarely. If it happens to you, then tell your doctor immediately. Do not take any more sumatriptan succinate injection, tablets, or
nasal spray unless your doctor tells you to do so.
Some people may have feelings of tingling, heat, flushing (redness of face lasting a short time), heaviness or pressure after
treatment with sumatriptan succinate injection, tablets, or nasal spray. A few people may feel drowsy, dizzy, tired or sick, (or
experience nasal irritation with the nasal spray only). Tell your doctor of these symptoms at your next visit.
If you should feel unwell in any other way or have symptoms that you do not understand, you should contact your doctor immediately.
NOTE for Injection: You may experience pain or redness at site of injection, but this usually lasts less than an hour.
What to do if an Overdose is Taken
If you have taken more medication than you have been told, contact either your doctor, hospital emergency department, or nearest
poison control center immediately.
Storing Your Medicine
Keep your medicine in a safe place where children cannot reach it. It may be harmful to children. Store your medication from heat
and light. Tablets and Nasal Spray: Do not store at temperatures above 30°C (86°F) or below 2°C (36°F).
If your medication has expired (the expiration date is printed on the treatment pack), throw it away as instructed.
If your doctor decides to stop treatment, do not keep any leftover medicine unless your doctor tells you to. Throw away your medicine
For Injection: Do not throw away your autoinjector. Keep your medication in the case provided and do not store at temperatures above
30 °C (86 °F).
Ergot-containing drugs have been reported to cause prolonged vasospastic reactions. Because there is a theoretical basis that these effects may be additive, use of ergotamine-containing or ergot-type medications (like dihydroergotamine or methysergide) and sumatriptan within 24 hours of each other should be avoided.
MAO-A inhibitors reduce sumatriptan clearance, significantly increasing systemic exposure. Therefore, the use of sumatriptan succinate tablets in patients receiving MAO-A inhibitors is contraindicated .
Selective serotonin reuptake inhibitors (SSRIs) (e.g., fluoxetine, fluvoxamine, paroxetine, sertraline) have been reported, rarely, to cause weakness, hyperreflexia, and incoordination when coadministered with sumatriptan. If concomitant treatment with sumatriptan and an SSRI is clinically warranted, appropriate observation of the patient is advised.
Sumatriptan succinate tablets should not be given to patients with history, symptoms, or signs of ischemic cardiac, cerebrovascular, or peripheral vascular syndromes. In addition, patients with other significant underlying cardiovascular diseases should not receive sumatriptan succinate tablets. Ischemic cardiac syndromes include, but are not limited to, angina pectoris of any type (e.g., stable angina of effort and vasospastic forms of angina such as the Prinzmetal variant), all forms of myocardial infarction, and silent myocardial ischemia. Cerebrovascular syndromes include, but are not limited to, strokes of any type as well as transient ischemic attacks. Peripheral vascular disease includes, but is not limited to, ischemic bowel disease .
Because sumatriptan succinate tablets may increase blood pressure, they should not be given to patients with uncontrolled hypertension.
Concurrent administration of MAO-A inhibitors or use within 2 weeks of discontinuation of MAO-A inhibitor therapy is contraindicated (see CLINICAL PHARMACOLOGY, Drug Interactions and DRUG INTERACTIONS).
Sumatriptan succinate tablets should not be administered to patients with hemiplegic or basilar migraine.
Sumatriptan succinate tablets and any ergotamine-containing or ergot-type medication (like dihydroergotamine or methysergide) should not be used within 24 hours of each other, nor should sumatriptan succinate and another 5-HT1 agonist.
Sumatriptan succinate tablets are contraindicated in patients with hypersensitivity to sumatriptan or any of their components.
Sumatriptan succinate tablets are contraindicated in patients with severe hepatic impairment.
Additional information about SumatranSumatran Indication: For the treatment of migraine attacks with or without aura in adults
Mechanism Of Action: Sumatran stimulates 5-HT receptors of the 1D subtype, most likely presynaptic receptors, resulting in selective vasoconstriction of inflamed and dilated cranial blood vessels in the carotid circulation. Sumatran also blocks the release of vasoactive neuropeptides from perivascular trigeminal axons in the dura mater during migraine and may inhibit the release of inflammatory mediators from the trigeminal nerve.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Sumatriptan
Synonyms: Sumatriptan Succinate; Sumatriptanum [Inn-Latin]; NP101
Drug Category: Vasoconstrictor Agents; Selective Serotonin Agonists
Drug Type: Small Molecule; Approved; Investigational
Other Brand Names containing Sumatriptan: Imigran; Sumatran; Sumax; Imitrex;
Absorption: Approximately 15%
Toxicity (Overdose): Symptoms of overdose include convulsions, tremor, paralysis, inactivity, ptosis, erythema of the extremities, abnormal respiration, cyanosis, ataxia, mydriasis, salivation, and lacrimation.
Protein Binding: 14%-21%
Biotransformation: Hepatic. In vitro studies with human microsomes suggest that sumatriptan is metabolized by monoamine oxidase (MAO), predominantly the A isoenzyme.
Half Life: 2.5 hours
Dosage Forms of Sumatran: Liquid Subcutaneous
Patch, extended release Transdermal
Chemical IUPAC Name: 1-[3-(2-dimethylaminoethyl)-1H-indol-5-yl]-N-methylmethanesulfonamide
Chemical Formula: C14H21N3O2S
Sumatriptan on Wikipedia: http://en.wikipedia.org/wiki/Sumatriptan
Organisms Affected: Humans and other mammals
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