Syndopa - General Information:

The naturally occurring form of dihydroxyphenylalanine and the immediate precursor of dopamine. Unlike dopamine itself, it can be taken orally and crosses the blood-brain barrier. It is rapidly taken up by dopaminergic neurons and converted to dopamine. It is used for the treatment of parkinsonian disorders and is usually given with agents that inhibit its conversion to dopamine outside of the central nervous system. [PubChem]


Syndopa (L-dopa) is used to replace dopamine lost in Parkinson's disease because dopamine itself cannot cross the blood-brain barrier where its precursor can. However, L-DOPA is converted to dopamine in the periphery as well as in the CNS, so it is administered with a peripheral DDC (dopamine decarboxylase) inhibitor such as carbidopa, without which 90% is metabolised in the gut wall, and with a COMT inhibitor if possible; this prevents about a 5% loss. The form given therapeutically is therefore a prodrug which avoids decarboxylation in the stomach and periphery, can cross the blood-brain barrier, and once in the brain is converted to the neurotransmitter dopamine by the enzyme aromatic-L-amino-acid decarboxylase.

Syndopa for patients

Stopping this medication suddenly can cause Parkinson's disease to worsen quickly. Report bothersome or unexpected side effects. Unless prescribed, do not take levodopa in addition to this drug. Avoid pyridoxine (vitamin B6) if you are taking levodopa alone, although it can be taken with carbidopa/levodopa. Avoid high-protein meals for maximum absorption. If you are taking the sustained-release tablet, swallow a whole or one-half tablet without chewing or crushing it. Onset of effect of the first morning dose of the sustained release product could be delayed up to 1 hour compared with the quick-release product. A dark color (red, brown, or black) might appear in saliva, urine, or sweat and can stain clothing.

Syndopa Interactions

Syndopa Contraindications

Monoamine oxidase (MAO) inhibitors and Larodopa should not be given concomitantly and these inhibitors must be discontinued 2 weeks prior to initiating therapy with Larodopa. Larodopa is contraindicated in patients with known hypersensitivity to the drug and in narrow angle glaucoma.

Because levodopa may activate a malignant melanoma, it should not be used in patients with suspicious, undiagnosed skin lesions or a history of melanoma.

Syndopa more info

Indication, Mechanism Of Action, Drug Interactions, Food Interactions, etc..