Synkavite - General Information:

A synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo. [PubChem]

Pharmacology:

Synkavite (Vitamin K3) is a fat-soluble vitamin precursor that is converted into menaquinone in the liver. Vitamin K1 and K2 are the naturally occurring types of vitamin K. The former, which is also known as phylloquinone, is synthesized by plants and can be found in such foods as spinach, broccoli, lettuce, and soybeans. The latter, sometimes alternatively referred to as menaquinone, is primarily produced by bacteria in the anterior part of the gut and the intestines. Vitamin K3, on the other hand, is one of the many manmade versions of vitamin K. Also called menadione, this yellowish, synthetic crystalline substance is converted into the active form of the K2 vitamin inside of the animal body. While a vitamin K deficiency can be dangerous, especially to infants that may easily suffer from extensive hemorrhaging, an overdose can be as equally detrimental. Newborns that are administered too great a dosage of vitamin K3 can suffer from kernicterus, a form of severe brain damage that may produce decreased movement, loss of appetite, seizures, deafness, mental retardation, and even death. This condition is associated with an abnormally high concentration of bilirubin, a bile pigment, in the tissues of the brain, which can be caused by the presence of K3. For this reason, K3 is less often utilized medically than it was in former times.

Synkavite for patients

Synkavite Interactions

Broad-Spectrum Antibiotics-Broad-spectrum antibiotics may sterilize the bowel and decrease the vitamin K contribution to the body by the intestinal microflora. Cephalosporins-Cephalosporins containing side chains of N-methylthiotetrazole (cefmenoxime, cefoperazone, cefotetan, cefamandole, latamoxef) or methylthiadiazole (cefazolin) can cause vitamin K deficiency and hypoprothrombinemia. These cephalosporins are inhibitors of hepatic vitamin K epoxide reductase. Cholestyramine-Concomitant intake of cholestyramine and vitamin K may reduce the absorption of vitamin K. Colestipol-Concomitant intake of colestipol and vitamin K may reduce the absorption of vitamin K. Mineral Oil-Concomitant intake of mineral oil and vitamin K may reduce the absorption of vitamin K. Orlistat-Orlistat may decrease the absorption of vitamin K. Salicylates-Salicylates in large doses may inhibit vitamin K epoxide reductase resulting in vitamin K deficiency. Warfarin-Vitamin K can antagonize the effect of warfarin

Synkavite Contraindications

  • Vitamin K is contraindicated in those hypersensitive to any component of a vitamin K-containing product.
  • Contraindicated in patients with severe hepatic disease.
  • Contraindicated in women in the last few weeks of pregnancy.

Other Brand Names containing Menadione:

Synkavite; Synkayvite; Kappaxin; Klottone; Panosine; Kolklot; Kayklot;

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Indication, Mechanism Of Action, Drug Interactions, Food Interactions, etc..