Tigan - General Information:Tigan is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against emesis induced by intragastric copper sulfate.
Pharmacology:Tigan is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against emesis induced by intragastric copper sulfate.
Tigan for patients
No specific information available.
Use of the injectable form of Tigan® in children, the suppositories in premature or newborn infants, and use of any dosage form in patients with known hypersensitivity to trimethobenzamide are contraindicated. Since the suppositories contain benzocaine they should not be used in patients known to be sensitive to this or similar local anesthetics.
Additional information about TiganTigan Indication: For the treatment of postoperative nausea and vomiting and for nausea associated with gastroenteritis.
Mechanism Of Action: The mechanism of action of trimethobenzamide as determined in animals is obscure, but may involve the chemoreceptor trigger zone (CTZ), an area in the medulla oblongata through which emetic impulses are conveyed to the vomiting center; direct impulses to the vomiting center apparently are not similarly inhibited.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Trimethobenzamide
Synonyms: Trimethobenzamide hydrochloride; Trimethobenzamide HCL; Trimethobenzamidum [INN-Latin]; Trimetobenzamida [INN-Spanish]
Drug Category: Antiemetics
Drug Type: Small Molecule; Approved
Other Brand Names containing Trimethobenzamide: Ametik hydrochloride; Benzacot; Nauseton; Stemetic; Tebamide; Tigan; Tribenzagan; Trimazide;
Absorption: The relative bioavailability of the capsule formulation compared to the solution is 100%.
Toxicity (Overdose): Oral LD50 in mice is 1600 mg/kg.
Protein Binding: Not Available
Half Life: The mean elimination half-life of trimethobenzamide is 7 to 9 hours.
Dosage Forms of Tigan: Capsule Oral
Injection, solution Intramuscular
Chemical IUPAC Name: N-[[4-(2-dimethylaminoethoxy)phenyl]methyl]-3,4,5-trimethoxybenzamide
Chemical Formula: C21H28N2O5
Trimethobenzamide on Wikipedia: http://en.wikipedia.org/wiki/Trimethobenzamide
Organisms Affected: Humans and other mammals
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