Trancopal - General Information:

A non-benzodiazepine that is used in the management of anxiety. It has been suggested for use in the treatment of muscle spasm. [PubChem]

Pharmacology:

Trancopal is a non-benzodiazepine muscle relaxant. It was discontinued worldwide in 1996 by its manufacturer due to confirmed serious and rare cutaneous reactions (toxic epidermal necrolysis).

Additional information about Trancopal

Trancopal Indication: Used in the management of anxiety and in the treatment of muscle spasm.
Mechanism Of Action: Trancopal binds to central benzodiazepine receptors which interact allosterically with GABA receptors. This potentiates the effects of the inhibitory neurotransmitter GABA, increasing the inhibition of the ascending reticular activating system and blocking the cortical and limbic arousal that occurs following stimulation of the reticular pathways.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Chlormezanone
Synonyms: Chlormezanone [BAN:INN:JAN]; Chlormezanon; Chlormezanonum [INN-Latin]; Chlormethazanone; Chlormethazone; Clormetazanone; Clormetazon; Clormezanona [INN-Spanish]; Clormezanone [DCIT]; Dichloromethazanone; Dichloromezanone; dl-Chlormezanone
Drug Category: Antipsychotics; Anti-anxiety Agents; Benzodiazepines; Muscle Relaxants, Central
Drug Type: Small Molecule; Approved; Withdrawn
Other Brand Names containing Chlormezanone: Alinam; Banabil-sintyal; Banabin; Banabin-Sintyal; Banabin-syntyal; Bisina; Chlomedinon; Clorilax; Lobak; Mio-Sed; Miorilax; Muskel; Muskel-Trancopal; Myolespen; Phenarol; Rexan; Rilansyl; Rilaquil; Rilasol; Rilassol; Rilax; Rillasol; Supotran; Suprotan; Tanafol; Trancopal; Trancote; Tranrilax; Transanate;
Absorption: Not Available
Toxicity (Overdose): Symptoms of overdose include drowsiness, weakness, nausea, dizziness, abdominal pain, cerebral oedema and renal tubular necrosis, hyperglycaemia and hypoglycaemia, liver damage, encephalopathy, coma and death.
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Trancopal: Not Available
Chemical IUPAC Name: 2-(4-chlorophenyl)-3-methyl-1,1-dioxo-1,3-thiazinan-4-one
Chemical Formula: C11H12ClNO3S
Chlormezanone on Wikipedia: http://en.wikipedia.org/wiki/Chlormezanone
Organisms Affected: Humans and other mammals

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