Trapanal - General Information:
A barbiturate that is administered intravenously for the induction of general anesthesia or for the production of complete anesthesia of short duration. It is also used for hypnosis and for the control of convulsive states. It has been used in neurosurgical patients to reduce increased intracranial pressure. It does not produce any excitation but has poor analgesic and muscle relaxant properties. Small doses have been shown to be anti-analgesic and lower the pain threshold. (From Martindale, The Extra Pharmacopoeia, 30th ed, p920)
Trapanal, a barbiturate, is used for the induction of anesthesia prior to the use of other general anesthetic agents and for induction of anesthesia for short surgical, diagnostic, or therapeutic procedures associated with minimal painful stimuli. Trapanal is an ultrashort-acting depressant of the central nervous system which induces hypnosis and anesthesia, but not analgesia. It produces hypnosis within 30 to 40 seconds of intravenous injection. Recovery after a small dose is rapid, with some somnolence and retrograde amnesia. Repeated intravenous doses lead to prolonged anesthesia because fatty tissues act as a reservoir; they accumulate Pentothal in concentrations 6 to 12 times greater than the plasma concentration, and then release the drug slowly to cause prolonged anesthesia
Trapanal for patients
The following drug interactions have been reported with thiopental.
|Probenecid||Prolonged action of thiopental|
|Opioid analgesics||Decreased antinociceptive action|
- Absence of suitable veins for intravenous administration,
- hypersensitivity (allergy) to barbiturates and
- variegate porphyria (South African) or acute intermittent porphyria.
- Severe cardiovascular disease,
- hypotension or shock,
- conditions in which the hypnotic effect may be prolonged or potentiated ó excessive premedication, Addisonís disease, hepatic or renal dysfunction, myxedema, increased blood urea, severe anemia, asthma, myasthenia gravis, and
- status asthmaticus.
Diluents in Pentothal® Kits
Ready-To-Mix Syringes and Vials
(For preparing solutions of Thiopental Sodium for Injection, USP)
Do not use unless the diluent is clear and the bottle or vial seal or syringe package is undamaged.
Diluents in Pentothal Kits, Ready-to-Mix Syringes or Vials should not be used for fluid or sodium chloride replacement.
Indication, Mechanism Of Action, Drug Interactions, Food Interactions, etc..