Trimedal - General Information:

An anticonvulsant effective in absence seizures, but generally reserved for refractory cases because of its toxicity. (From AMA Drug Evaluations Annual, 1994, p378)

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Trimedal - Pharmacology:

Dione anticonvulsants reduce T-type calcium currents in thalamic neurons, including thalamic relay neurons. This raises the threshold for repetitive activity in the thalamus, and inhibits corticothalamic transmission. Thus, the abnormal thalamocortical rhythmicity, which is thought to underlie the 3-Hz spike-and-wave discharge seen on electroencephalogram(EEG) with absence seizures, is dampened.

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Trimedal Contraindications

Contraindicated in liver disease, kidney disease, retinal or optic nerve (eye) disease, a disease of the blood or bone marrow, and acute intermittent porphyria.

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