Trimpex 200 - General Information:

A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to pyrimethamine. The interference with folic acid metabolism may cause a depression of hematopoiesis. It is potentiated by sulfonamides and the trimethoprim-sulfamethoxazole combination is the form most often used. It is sometimes used alone as an antimalarial. trimethoprim resistance has been reported. [PubChem]

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Bactrim (Sulfamethoxazole / Trimethoprim) is an antibiotic combination used to treat or prevent infections.

Pharmacology:

Trimpex 200, a synthetic antiinfective agent, is used to treat and prevent urinary tract infections, diarrhea, and, when combined with either sulfamethoxazole or dapsone, Pneumocystis carinii infections.

Trimpex 200 for patients

Trimpex 200 Interactions

Trimethoprim may inhibit the hepatic metabolism of phenytoin. Trimethoprim, given at a common clinical dosage, increased the phenytoin half-life by 51% and decreased the phenytoin metabolic clearance rate by 30%. When administering these drugs concurrently, one should be alert for possible excessive phenytoin effect.

Trimpex 200 Contraindications

Trimethoprim is contraindicated in individuals hypersensitive to trimethoprim and in those with documented megaloblastic anemia due to folate deficiency.

Additional information about Trimpex 200

Trimpex 200 Indication: For the treatment of initial episodes of uncomplicated urinary tract infections
Mechanism Of Action: Trimpex 200 binds to bacterial dihydrofolate reductase, subsequently interfering with the uptake of p-aminobenzoic acid (PABA) into folic acid. As folic acid is a coenzyme responsible for the transport of one-carbon fragments from one molecule to another, it is an essential component of bacterial development. Sulfonamides inhibit bacterial dihydrofolate synthetase, the enzyme immediately preceding dihydrofolate reductase, and therefore act synergistically with trimethoprim.
Drug Interactions: Not Available
Food Interactions: Take on empty stomach: 1 hour before or 2 hours after meals.
Take with a full glass of water.
Do not take calcium, aluminium, magnesium or iron supplements within 2 hours of taking this medication.
Generic Name: Trimethoprim
Synonyms: Not Available
Drug Category: Antimalarials; Anti-Infectives
Drug Type: Small Molecule; Approved
Other Brand Names containing Trimethoprim: Abacin; Abaprim; Alprim; Apo-Sulfatrim; Bactin; Bactramin; Bactrim; Bactrim DS; Bactrim Pediatric; Baktar; Chemotrim; Co-Trimoxazole; Comox; Cotrim; Cotrim D.S.; Drylin; Eusaprim; Fectrim; Gantaprim; Gantrim; Idotrim; Imexim; Instalac; Ipral; Kepinol; Laratrim; Lidaprim; Linaris; Methoprim; Microtrim; Monoprim; Monotrim; Monotrimin; Nopil; Oraprim; Priloprim; Primosept; Primsol; Proloprim; Septra; Septra DS; Septra Grape; Septrin; Sigaprim; Sulfamethoprim; Sulfamethoprim-DS; Sulfamethoxazole & Trimethoprim; Sulfatrim; Sulfatrim Pediatric; Sulfatrim-DS; Sulfatrim-SS; Sulfotrim; Sulmeprim; Sulmeprim Pediatric; Sulprim; Sumetrolim; Supracombin; Suprim; Syraprim; Teleprim; Thiocuran; Tiempe; Tmp-Ratiopharm; Trigonyl; Trimanyl; Trimesulf; Trimeth/Sulfa; Trimethioprim; Trimethopriom; Trimetoprim; Trimexazole; Trimogal; Trimopan; Trimpex; Trimpex 200; Triprim; Unitrim; Uretrim; Uro-Septra; Uroplus; Uroplus DS; Uroplus SS; Wellcoprim;
Absorption: Not Available
Toxicity (Overdose): LD50=4850 (orally in mice)
Protein Binding: Approximately 45%
Biotransformation: Not Available
Half Life: 8-10 hours
Dosage Forms of Trimpex 200: Tablet Oral
Chemical IUPAC Name: 5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine
Chemical Formula: C14H18N4O3
Trimethoprim on Wikipedia: http://en.wikipedia.org/wiki/Trimethoprim
Organisms Affected: Gram negative and gram positive bacteria

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