Trosyd - General Information:

Trosyd is an antifungal medication of the Imidazole class used to treat infections caused by a fungus or yeast. Trosyd topical (skin) preparations are also available for ringworm, jock itch, athlete's foot, and tinea versicolor or "sun fungus". Trosyd interacts with 14-± demethylase, a cytochrome P-450 enzyme that converts lanosterol to ergosterol, an essential component of the yeast membrane. In this way, tioconazole inhibits ergosterol synthesis, resulting in increased cellular permeability.

Pharmacology:

Trosyd is a broad-spectrum imidazole antifungal agent that inhibits the growth of human pathogenic yeasts. Trosyd exhibits fungicidal activity in vitro against Candida albicans, other species of the genus Candida, and against Torulopsis glabrata. Trosyd prevents the growth and function of some fungal organisms by interfering with the production of substances needed to preserve the cell membrane. This drug is effective only for infections caused by fungal organisms. It will not work for bacterial or viral infections.

Trosyd for patients

The VAGISTAT-1 ointment base may interact with rubber or latex products such as condoms or vaginal contraceptive diaphragms; therefore, use of such products within 72 hours following treatment is not recommended.

Trosyd Interactions

Trosyd Contraindications

VAGISTAT-1 is contraindicated in individuals who have been shown to be sensitive to imidazole antifungal agents or to other components of the ointment.

Additional information about Trosyd

Trosyd Indication: For the local treatment of vulvovaginal candidiasis (moniliasis).
Mechanism Of Action: Trosyd interacts with 14-α demethylase, a cytochrome P-450 enzyme that converts lanosterol to ergosterol, an essential component of the yeast membrane. In this way, tioconazole inhibits ergosterol synthesis, resulting in increased cellular permeability. Trosyd may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms and the uptake of purine, impair triglyceride and/or phospholipid biosynthesis, and inhibit the movement of calcium and potassium ions across the cell membrane by blocking the ion transport pathway known as the Gardos channel.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Tioconazole
Synonyms: Tioconazol [INN-Spanish]; Tioconazolum [INN-Latin]
Drug Category: Antifungal Agents
Drug Type: Small Molecule; Approved
Other Brand Names containing Tioconazole: Fungibacid; GyneCure; Gyno-trosyd; Monistat 1; Trosyd; Trosyd AF; Trosyd J; Trosyl; Tz-3; Vagistat; Vagistat-1; Zoniden;
Absorption: Systemic absorption following a single intravaginal application of tioconazole in nonpregnant patients is negligible.
Toxicity (Overdose): Symptoms of overdose include erythema, stinging, blistering, peeling, edema, pruritus, urticaria, burning,
and general irritation of the skin, and cramps.
Protein Binding: Not Available
Biotransformation: Orally administered tioconazole is extensively metabolized. The major metabolites are glucuronide conjugates.
Half Life: Not Available
Dosage Forms of Trosyd: Ointment Intravaginal
Chemical IUPAC Name: 1-[2-[(2-chlorothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole
Chemical Formula: C16H13Cl3N2OS
Tioconazole on Wikipedia: http://en.wikipedia.org/wiki/Tioconazole
Organisms Affected: Yeast and other fungi

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