Flexyx

Flexyx drugs: Ulgarine

Ulgarine - General Information:

A competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion. [PubChem]

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Pepcid (Famotidine) - for $38.16 Pepcid blocks the action of histamine on stomach cells, and reduces stomach acid production. Pepcid is useful in promoting the healing of stomach and duodenal ulcers and in reducing ulcer pain. Pepcid has been effective in preventing recurrence of ulcers when given in low doses for prolonged periods of time. Pepcid also is used for treating heartburn and in healing ulceration and inflammation of the esophagus (esophagitis) resulting from acid (gastroesophageal reflux disease or GERD). High doses are used for treating conditions in which there are marked increases in acid secretion such as Zollinger-Ellison syndrome.

* >> all this drugs based on Famotidine (usually they can be used instead of Ulgarine)

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Generic Pepcid (Famotidine) - 20mg 100 pills for $22.86 Pepcid (Famotidine) is a histamine blocker used to treat and prevent ulcers. It is also used to treat Gastroesophageal Reflux Disease (GERD). This medicine may also be used to treat other conditions as determined by your doctor.

Pharmacology:

Ulgarine, a competitive histamine H₂-receptor antagonist, is used to treat gastrointestinal disorders such as gastric or duodenal ulcer, gastroesophageal reflux disease, and pathological hypersecretory conditions. Ulgarine inhibits many of the isoenzymes of the hepatic CYP450 enzyme system. Other actions of Ulgarine include an increase in gastric bacterial flora such as nitrate-reducing organisms.

Ulgarine for patients

Famotidine is used to treat stomach and duodenal (upper small intestine) ulcers;
hypersecretory (increased acid secretion) conditions; heartburn and gastroesophageal
reflux disease (stomach contents bubbling into the esophagus causing pain). Notify your
physician if you are pregnant or nursing. Famotidine may be taken with or without food.
Shake the oral suspension vigorously for 5-10 seconds before taking. Unused oral
suspension should be discarded after 30 days. Notify your physician if you develop black,
tarry stools or coffee-ground vomit.

Ulgarine Interactions

No drug interactions have been identified. Studies with famotidine in man, in animal models, and in vitro have shown no significant interference with the disposition of compounds metabolized by the hepatic microsomal enzymes, e.g., cytochrome P450 system. Compounds tested in man include warfarin, theophylline, phenytoin, diazepam, aminopyrine and antipyrine. Indocyanine green as an index of hepatic drug extraction has been tested and no significant effects have been found.

Ulgarine Contraindications

Hypersensitivity to any component of these products. Cross sensitivity in this class of compounds has been observed. Therefore, PEPCID should not be administered to patients with a history of hypersensitivity to other H₂-receptor antagonists.

Additional information about Ulgarine

Ulgarine Indication: For the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD).
Mechanism Of Action: Ulgarine binds competitively to H₂-receptors located on the basolateral membrane of the parietal cell, blocking histamine affects. This competitive inhibition results in reduced basal and nocturnal gastric acid secretion and a reduction in gastric volume, acidity, and amount of gastric acid released in response to stimuli including food, caffeine, insulin, betazole, or pentagastrin.
Drug Interactions: Atazanavir This gastric pH modifier decreases the levels/effects of atazanavir
Enoxacin The agent decreases the absorption of enoxacin
Itraconazole The anti-H2 decreases the absorption of the imidazole
Ketoconazole The anti-H2 decreases the absorption of the imidazole
Food Interactions: Take without regard to meals, food may slightly increase the product's bioavailability.
Limit caffeine intake.
Avoid alcohol.
Generic Name: Famotidine
Synonyms: Famotidina [Spanish]; Famotidinum [Latin]
Where to order Famotidine (and Ulgarine analogs) online:
Drug Category: Anti-Ulcer Agents; Histamine H2 Antagonists
Drug Type: Small Molecule; Approved
Other Brand Names containing Famotidine: Amfamox; Antodine; Apo-Famotidine; Apogastine; Bestidine; Blocacid; Brolin; Cepal; Confobos; Cronol; Cuantin; Dibrit 40; Digervin; Dinul; Dipsin; Dispromil; Dispronil; Duovel; Durater; Evatin; Fadin; Fadine; Fadyn; Fagastine; Famo; Famocid; Famodar; Famodil; Famodin; Famodine; Famogard; Famonit; Famopsin; Famos; Famosan; Famotal; Famotep; Famotin; Famovane; Famowal; Famox; Famoxal; Famtac; Famulcer; Fanobel; Fanosin; Fanox; Farmotex; Ferotine; Fibonel; Fluxid; Fudone; Ganor; Gaster; Gastridan; Gastridin; Gastrion; Gastro; Gastrodomina; Gastrofam; Gastropen; Gastrosidin; H2 Bloc; Hacip; Huberdina; Ingastri; Invigan; Lecedil; Logos; Mensoma; Midefam; Mosul; Motiax; Muclox; Mylanta AR; Neocidine; Nevofam; Notidin; Novo-Famotidine; Nu-Famotidine; Nulceran; Nulcerin; Panalba; Pepcid; Pepcid AC; Pepcid RPD; Pepcidin; Pepcidin Rapitab; Pepcidina; Pepcidine; Pepdif; Pepdine; Pepdul; Pepfamin; Peptan; Peptidin; Peptifam; Pepzan; Purifam; Quamatel; Quamtel; Renapepsa; Restadin; Rogasti; Rubacina; Sedanium-R; Sigafam; Supertidine; Tairal; Tamin; Tipodex; Topcid; Ulcatif; Ulceprax; Ulcofam; Ulfagel; Ulfam; Ulfamid; Ulfinol; Ulgarine; Vagostal; Weimok; Whitidin; Yamarin;
Absorption: The bioavailability of oral doses is 40-45%.
Toxicity (Overdose): Intravenous, mouse: LD₅₀ = 244.4mg/kg; Oral, mouse: LD₅₀ = 4686 mg/kg. Symptoms of overdose include emesis, restlessness, pallor of mucous membranes or redness of mouth and ears, hypotension, tachycardia and collapse.
Protein Binding: 15-20%
Biotransformation: Hepatic.
Half Life: 2.5-3.5 hours
Dosage Forms of Ulgarine: Solution Intravenous
Tablet Oral
Chemical IUPAC Name: 3-[[2-(diaminomethylideneamino)-1,3-thiazol-4-yl]methylsulfanyl]-N'-sulfamoylpropanimidamide
Chemical Formula: C8H15N7O2S3
Famotidine on Wikipedia: http://en.wikipedia.org/wiki/Famotidine
Organisms Affected: Humans and other mammals