Urinex - General Information:

A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812)

Pharmacology:

Like other thiazides, chlorothiazide promotes water loss from the body (diuretics). It inhibits Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue. Urinex affects the distal renal tubular mechanism of electrolyte reabsorption. At maximal therapeutic dosages, all thiazides are approximately equal in their diuretic efficacy. Urinex increases excretion of sodium and chloride in approximately equivalent amounts. Natriuresis may be accompanied by some loss of potassium and bicarbonate. After oral doses, 10-15 percent of the dose is excreted unchanged in the urine. Urinex crosses the placental but not the blood-brain barrier and is excreted in breast milk.

Urinex for patients

For treatment of high blood pressure, you must take chlorothiazide regularly for it to be effective. As blood pressure declines gradually, it can take several weeks before you experience the full benefit of chlorothiazide, and you must continue taking it even if you are feeling well. Note that chlorothiazide does not cure high blood pressure, it simply keeps it under control.

Urinex Interactions

When given concurrently the following drugs may interact with thiazide diuretics.

- Alcohol, barbiturates, or narcotics: Potentiation of otthostatic hypotension may occur.
- Antidiabetic drugs: (Oral agents and insulin) Dosage adjustment of the antidiabetic drug may be required.
- Other antihypertensive drugs: Additive effect or potentiation.
- Cholestyramine and colestipol resins: Cholestytamine and colestipol resins have the potential of binding thiazide diuretics and reducing diuretic absorption from the gastrointestinal tract.
- Corticosteroids, ACTH: Intensified electrolyte depletion, particularly hypokalemia.
- Pressor amines (e.g., norepinephrine): Possible decreased response to pressor amines but not sufficient to preclude their use.
- Skeletal muscle relaxants, nondepolarizing (e.g., tubocurarine): Possible increased responsiveness to the muscle relaxant.
- Lithium: Generally should not be given with diuretics. Diuretic agents reduce the renal clearance of lithium and add a high risk of lithium toxicity. Refer to the package insert for lithium preparations before use of such preparations with chlorothiazide.
- Non-steroidal Anti-inflammatory Drugs: In some patients, the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics. Therefore, when chlorothiazide and non-steroidal anti-inflammatory agents are used concomitantly, the patient should be observed closely to determine if the desired effect of the diuretic is obtained.
- Drug/Laboratory Test Interactions: Thiazides should be discontinued before carrying out tests for parathyroid function.

Urinex Contraindications

Anuria.

Hypersensitivity to this or other sulfonamide-derived drugs.

Urinex more info

Indication, Mechanism Of Action, Drug Interactions, Food Interactions, etc..