Valamin - General Information:

Valamin is a short-acting sedative-hypnotic medication used to treat insomnia. Regular use leads to tolerance, and it is usually not effective for more than 7 days. Structurally, it does not resemble the barbituates, but it shares many effects with this class of drugs; the depressant effects of ethinamate are, however, generally milder than those of most barbiturates.

Pharmacology:

Valamin is used to treat insomnia (trouble in sleeping). However, it has generally been replaced by other medicines for the treatment of insomnia. If ethinamate is used regularly (for example, every day) to help produce sleep, it is usually not effective for more than 7 days. Structurally, it does not resemble the barbiturates, but it shares many effects with this class of drugs; the depressant effects of ethinamate are, however, generally milder than those of most barbiturates. Continued and inappropriate use of ethinamate can lead to tolerance and physical dependence, with withdrawal symptoms very similar to those of the barbiturates.

Valamin for patients

Valamin Interactions

May interact with addictive medications, especially central nervous system (CNS) depressants with habituating potential (prolonged concurrent use may increase the risk of habituation), alcohol or CNS depression–producing medications (concurrent use may increase the CNS depressant effects of either these medications or ethinamate).

Valamin Contraindications

Contraindicated in alcoholism, drug abuse or dependence, history of (predisposition of patient to habituation or dependence), mental depression, pain, sensitivity to ethinamate.

Additional information about Valamin

Valamin Indication: Used for the short-term treatment of insomnia, however, it generally has been replaced by other sedative-hypnotic agents.
Mechanism Of Action: The mechanism of action is not known. However, studies have shown that ethinamate inhibits carbonic anhydrases I and II (J Biol Chem. 1992 Dec 15;267(35):25044-50). This inhibition by ethinamate is not sufficiently strong to implicate carbonic anhydrases I and II in the mechanism of action.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Ethinamate
Synonyms: USAF EL-42; Ethinamat; Ethinimate; Etinamate
Drug Category: Hypnotics and Sedatives
Drug Type: Small Molecule; Illicit; Approved
Other Brand Names containing Ethinamate: Valamin; Valaminettae; Valaminetten; Valmid; Valmidate; Volamin;
Absorption: Rapidly absorbed following oral administration.
Toxicity (Overdose): Symptoms of overdose include shortness of breath or slow or troubled breathing, slow heartbeat, severe weakness, chronic confusion, slurred speech, and staggering.
Protein Binding: Not Available
Biotransformation: Hepatic.
Half Life: 2.5 hours
Dosage Forms of Valamin: Not Available
Chemical IUPAC Name: (1-ethynylcyclohexyl) carbamate
Chemical Formula: C9H13NO2
Ethinamate on Wikipedia: http://en.wikipedia.org/wiki/Ethinamate
Organisms Affected: Humans and other mammals

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