Valpin 50 - General Information:

Anisotropine methylbromide is a quaternary ammonium compound. Its use as treatment adjunct in peptic ulcer has been replaced by the use of more effective agents. Depending on the dose, anisotropine methylbromide may reduce the motility and secretory activity of the gastrointestinal system, and the tone of the ureter and urinary bladder and may have a slight relaxant action on the bile ducts and gallbladder. In general, smaller doses of anisotropine methylbromide inhibit salivary and bronchial secretions, sweating, and accommodation; cause dilatation of the pupil; and increase the heart rate. Larger doses are required to decrease motility of the gastrointestinal and urinary tracts and to inhibit gastric acid secretion.

Pharmacology:

Anisotropine methylbromide is a quaternary ammonium compound. Its use as treatment adjunct in peptic ulcer has been replaced by the use of more effective agents. Depending on the dose, anisotropine methylbromide may reduce the motility and secretory activity of the gastrointestinal system, and the tone of the ureter and urinary bladder and may have a slight relaxant action on the bile ducts and gallbladder. In general, smaller doses of anisotropine methylbromide inhibit salivary and bronchial secretions, sweating, and accommodation; cause dilatation of the pupil; and increase the heart rate. Larger doses are required to decrease motility of the gastrointestinal and urinary tracts and to inhibit gastric acid secretion.

Additional information about Valpin 50

Valpin 50 Indication: For use in conjunction with antacids or histamine H2-receptor antagonists in the treatment of peptic ulcer, to reduce further gastric acid secretion and delay gastric emptying.
Mechanism Of Action: Quaternary ammonium compounds such as anisotropine methylbromide inhibit the muscarinic actions of acetylcholine on structures innervated by postganglionic cholinergic nerves as well as on smooth muscles that respond to acetylcholine but lack cholinergic innervation. These postganglionic receptor sites are present in the autonomic effector cells of the smooth muscle, cardiac muscle, sinoatrial and atrioventricular nodes, and exocrine glands.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Anisotropine Methylbromide
Synonyms: Not Available
Drug Category: Anticholinergics; Parasympatholytics
Drug Type: Small Molecule; Approved
Other Brand Names containing Anisotropine Methylbromide: Anisotropine methobromide; Endovalpin; Lytispasm; Methyloctatropine bromide; Octatropine; Valpin 50;
Absorption: Gastrointestinal absorption is poor and irregular. Total absorption after an oral dose is about 10 to 25%.
Toxicity (Overdose): Not Available
Protein Binding: Not Known
Biotransformation: Hepatic, by enzymatic hydrolysis.
Half Life: Not Known
Dosage Forms of Valpin 50: Not Available
Chemical IUPAC Name: [(1R,5R)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octan-3-yl] 2-propylpentanoate bromide
Chemical Formula: C17H32BrNO2
Anisotropine Methylbromide on Wikipedia: Not Available
Organisms Affected: Humans and other mammals

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