Flexyx

Flexyx drugs: Vanobid

Vanobid - General Information:

Vanobid is an antibiotic obtained from a streptomyces (Streptomyces griseus) and active against some fungi of the genus Candida (C. albicans). Vanobid is administered intravaginally in the treatment of vulvovaginal candidiasis.

Pharmacology:

Vanobid is a polyene antifungal antibiotic produced by a strain of Streptomyces griseus. It is especially effective against Candida albicans (more effective than amphotericin B), and is administered intravaginally in the treatment of vulvovaginal candidiasis.

Additional information about Vanobid

Vanobid Indication: Used in the topical treatment of vulvovaginal candidiasis.
Mechanism Of Action: Ergosterol, the principal sterol in the fungal cytoplasmic membrane, is the target site of action of Vanobid. Vanobid binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. There is some evidence that the binding site in the cell wall may be to fatty acids or fatty acid esters and that this binding capacity must be satisfied before candicidin can bring about its lethal effect by binding to sterol in the cell membrane.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Candicidin
Synonyms: Not Available
Drug Category: Anti-Bacterial Agents; Antifungal Agents
Drug Type: Small Molecule; Approved
Other Brand Names containing Candicidin: Candicidin A; Candicidin D; FR-008-III; Vanobid;
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Vanobid: Not Available
Chemical IUPAC Name: (19E,21E,23E,25E,27E,29E,31E)-33-[(3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-17-[7-(4-aminophenyl)-5-hydroxy-4-methyl-7-oxoheptan-2-yl]-1,3,5,7,37-pentahydroxy-18-methyl-9,13,15-trioxo-16,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
Chemical Formula: C59H84N2O18
Candicidin on Wikipedia: Not Available
Organisms Affected: Various Fungus Species