Vomex A - General Information:Vomex A (Dramamine, Gravol and Vertirosan) is an over-the-counter drug used to prevent motion sickness. It is closely related to diphenhydramine HCl, or Benadryl. It is primarily a H1-antagonist, but also possesses an antimuscarinic effect.
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Pharmacology:Vomex A is an antiemetics drug combination that contains diphenhydramine and theophylline. It is not effective in the treatment of nausea associated with cancer chemotherapy. Vomex A directly inhibits the stimulation of certain nerves in the brain and inner ear to suppress nausea, vomiting, dizziness, and vertigo.
Vomex A for patients
Vomex A Interactions
Dimenhydrinate may decrease emetic response to apomorphine.
Vomex A Contraindications
Dimenhydrinate may impede diagnosis of appendicitis and may obscure signs of overdose.
Additional information about Vomex AVomex A Indication: Used for treating vertigo, motion sickness, and nausea associated with pregnancy.
Mechanism Of Action: The mechanism by which some antihistamines exert their antiemetic, anti–motion sickness, and antivertigo effects is not precisely known but may be related to their central anticholinergic actions. They diminish vestibular stimulation and depress labyrinthine function. An action on the medullary chemoreceptive trigger zone may also be involved in the antiemetic effect.
Drug Interactions: Donepezil Possible antagonism of action
Galantamine Possible antagonism of action
Rivastigmine Possible antagonism of action
Food Interactions: Avoid alcohol.
Take with food.
Generic Name: Dimenhydrinate
Synonyms: Diphenhydramine Theoclate; Diphenhydrinate
Drug Category: Antiemetics; Histamine H1 Antagonists
Drug Type: Small Molecule; Approved
Other Brand Names containing Dimenhydrinate: Amosyt; Anautine; Andramine; Antemin; Aviomarin; Chloranautine; Diamarin; Dimate; Dimenest; Dimentabs; Dramalen; Dramamin; Dramarin; Dramilin; Dramyl; Dromyl; Eldodram; Gravinol; Gravol; Hydrinate; Menhydrinate; Neo-Navigan; Novamine; Permital; Reise-Engletten; Supremal; Teodramin; Travelin; Travelmin; Troversin; Vomex A; Xamamina;
Absorption: Well absorbed after oral administration.
Toxicity (Overdose): Symptoms of overdose include delerium and hallucinations.
Protein Binding: 98 to 99%.
Biotransformation: Hepatic (cytochrome P-450 system).
Half Life: 1 to 4 hours
Dosage Forms of Vomex A: Solution Intravenous
Tablet, multilayer Oral
Chemical IUPAC Name: 2-benzhydryloxyethyl-dimethylazanium; 8-chloro-1,3-dimethyl-2-oxopurin-6-olate
Chemical Formula: C24H28ClN5O3
Dimenhydrinate on Wikipedia: http://en.wikipedia.org/wiki/Dimenhydrinate
Organisms Affected: Humans and other mammals
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