Flexyx

Flexyx drugs: Wellferon (GlaxoSmithKline)

Wellferon (GlaxoSmithKline) - General Information:

Purified, natural (n is for natural) glycosylated human interferon alpha proteins 166 residues

Pharmacology:

Upregulates the expression of MHC I proteins, allowing for increased presentation of peptides derived from viral antigens. This enhances the activation of CD8+ T cells that are the precursors for cytotoxic T lymphocytes (CTLs) and makes the macrophage a better target for CTL-mediated killing. Interferon alpha also induce the synthesis of several key antiviral mediators, including 2'-5' oligoadenylate synthetase (2'-5' A synthetase) and protein kinase R.

Additional information about Wellferon (GlaxoSmithKline)

Wellferon (GlaxoSmithKline) Indication: For treatment of venereal or genital warts caused by the Human Papiloma Virus
Mechanism Of Action: Interferon alpha binds to type I interferon receptors (IFNAR1 and IFNAR2c) which, upon dimerization, activate two Jak (Janus kinase) tyrosine kinases (Jak1 and Tyk2). These transphosphorylate themselves and phosphorylate the receptors. The phosphorylated INFAR receptors then bind to Stat1 and Stat2 (signal transducers and activators of transcription)which dimerize and activate multiple (~100) immunomodulatory and antiviral proteins. Interferon alpha binds less stably to type I interferon receptors than interferon beta.
Drug Interactions: Aminophylline Interferon increases the effect and toxicity of theophylline
Dyphylline Interferon increases the effect and toxicity of theophylline
Oxtriphylline Interferon increases the effect and toxicity of theophylline
Theophylline Interferon increases the effect and toxicity of theophylline
Food Interactions: Avoid alcohol.
Generic Name: Interferon alfa-n1
Synonyms: Interferon alpha-2 precursor; Interferon alpha-A; LeIF A
Drug Category: Antiviral Agents; Immunomodulatory Agents
Drug Type: Biotech; Approved
Other Brand Names containing Interferon alfa-n1: Wellferon (GlaxoSmithKline);
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: 1.2 hours (mammalian reticulocytes, in vitro); >20 hours (yeast, in vivo); >10 hours (Escherichia coli, in vivo).
Dosage Forms of Wellferon (GlaxoSmithKline): Not Available
Chemical IUPAC Name: Human interferon alpha
Chemical Formula: C860H1353N227O255S9
Interferon alfa-n1 on Wikipedia: Not Available
Organisms Affected: Not Available