Wyamine - General Information:

A sympathomimetic agent with mainly indirect effects on adrenergic receptors. It is used to maintain blood pressure in hypotensive states, for example, following spinal anesthesia. Although the central stimulant effects of mephentermine are much less than those of amphetamine, its use may lead to amphetamine-type dependence. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1248)

Pharmacology:

Wyamine is a sympathomimetic agent with mainly indirect effects on adrenergic receptors. It is used to maintain blood pressure in hypotensive states, for example, following spinal anesthesia. Although the central stimulant effects of mephentermine are much less than those of amphetamine, its use may lead to amphetamine-type dependence. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1248)

Additional information about Wyamine

Wyamine Indication: Used to maintain blood pressure in hypotensive states.
Mechanism Of Action: Wyamine is an alpha adrenergic receptor agonist, but also acts indirectly by releasing endogenous norepinephrine. Cardiac output and systolic and diastolic pressures are usually increased. A change in heart rate is variable, depending on the degree of vagal tone. Sometimes the net vascular effect may be vasodilation. Large doses may depress the myocardium or produce central nervous system (CNS) effects.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Mephentermine
Synonyms: Mephetedrine; Mephenterdrinum; Mephenterdrine; Mefentermin; Mefenterdrin; N-methylphentermine
Drug Category: Adrenergic Agents; Adrenergic alpha-Agonists; Sympathomimetics; Vasoconstrictor Agents
Drug Type: Small Molecule; Approved
Other Brand Names containing Mephentermine: Wyfentermina; Wyamine; Vialin; Mephine;
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Hepatic, by N-demethylation and then p-hydroxylation.
Half Life: 17 to 18 hours.
Dosage Forms of Wyamine: Not Available
Chemical IUPAC Name: N,2-dimethyl-1-phenylpropan-2-amine
Chemical Formula: C11H17N
Mephentermine on Wikipedia: Not Available
Organisms Affected: Humans and other mammals

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