Flexyx

Flexyx drugs: Zenapax (Hoffmann-La Roche Inc)

Zenapax (Hoffmann-La Roche Inc) - General Information:

Humanized IgG1 Mab that binds to the human interleukin-2 receptor (anti-Tac or anti-CD25). Zenapax (Hoffmann-La Roche Inc) is a composite of human (90%) and murine (10%) antibody sequences. The human sequences were derived from the constant domains of human IgG1 and the variable framework regions of the Eu myeloma antibody. The murine sequences were derived from the complementarity-determining regions of a murine anti-Tac antibody.

Pharmacology:

Zenapax functions as an IL-2 receptor antagonist. Specifically it inhibits IL-2-mediated activation of lymphocytes, a critical pathway in the cellular immune response involved in allograft rejection.

Zenapax (Hoffmann-La Roche Inc) for patients

Zenapax (Hoffmann-La Roche Inc) Interactions

Zenapax (Hoffmann-La Roche Inc) Contraindications

ZENAPAX is contraindicated in patients with known hypersensitivity to Daclizumab or to any components of this product.

Additional information about Zenapax (Hoffmann-La Roche Inc)

Zenapax (Hoffmann-La Roche Inc) Indication: For prevention of renal transplant rejection
Mechanism Of Action: Zenepax binds with high-affinity to the Tac subunit of the high-affinity IL-2 receptor complex and inhibits IL-2 binding. The IL-2 receptor (Tac) subunit is expressed on activated but not resting lymphocytes.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Daclizumab
Synonyms: Ig gamma-1 chain C region; Anti-IL-2; Humanized antiCD25
Drug Category: Immunomodulatory Agents; Immunosuppressive Agents
Drug Type: Biotech; Approved; Investigational
Other Brand Names containing Daclizumab: Zenapax (Hoffmann-La Roche Inc);
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Most likely removed by opsonization via the reticuloendothelial system when bound to lymphocytes.
Half Life: 11-38 days
Dosage Forms of Zenapax (Hoffmann-La Roche Inc): Liquid Intravenous
Chemical IUPAC Name: Humanized anti-CD25 antibody
Chemical Formula: C6332H9808N1678O1989S42
Daclizumab on Wikipedia: http://en.wikipedia.org/wiki/Daclizumab
Organisms Affected: Humans and other mammals