Flexyx

Flexible discounts, flexible services!

Flexyx drugs: Zesulan

Zesulan - General Information:

Zesulan is a histamine H1 antagonist (antihistamine). It competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies.

Pharmacology:

In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once released, histamine can react with local or widespread tissues through histamine receptors. Histamine, acting on H₁-receptors, produces pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Zesulan is a histamine H1 antagonist. It competes with histamine for the normal H₁-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies.

Zesulan for patients

Zesulan Interactions

Mequitazine can interact with CNS depressant, antichlolinergic, TCA, MAOIs, and alcohol.

Zesulan Contraindications

Prostatic adenoma
Closed Angle Glaucoma
Paralytic ileus
Stenosis of the pylore
Myasthenia Gravis
Status Asthmaticus
Obstructive chronic broncho-pneumopath
Hypersensitivity to the Phenothiazines
concomitant MAOI therapy
Alcohol

Additional information about Zesulan

Zesulan Indication: For the treatment of Hay fever, urticaria (hives) and allergic rhinitis
Mechanism Of Action: Zesulan binds to the histamine H1 receptor sites on effector cells in the gastrointestinal tract, blood vessels, and respiratory tract. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Mequitazine
Synonyms: Mequitazina [Inn-Spanish]; Mequitazina [Spanish]; Mequitazinum [Inn-Latin]
Where to order Mequitazine (and Zesulan analogs) online:
Drug Category: Bronchodilator Agents; Histamine H1 Antagonists
Drug Type: Small Molecule; Approved
Other Brand Names containing Mequitazine: Butix; Instotal; Kitazemin; Metaplexan; Mircol; Primalan; Vigigan; Virginan; Zesulan;
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Zesulan: Not Available
Chemical IUPAC Name: 10-(1-azabicyclo[2.2.2]octan-8-ylmethyl)phenothiazine
Chemical Formula: C20H22N2S
Mequitazine on Wikipedia: http://en.wikipedia.org/wiki/Mequitazine
Organisms Affected: Humans and other mammals